Sengupta J, Talwar D, Paria B C, Ghosh D
Department of Physiology, All India Institute of Medical Sciences, New Delhi.
Acta Endocrinol (Copenh). 1988 May;118(1):142-6. doi: 10.1530/acta.0.1180142.
beta-glucuronidase, cathepsin D, acid and alkaline phosphatases were studied in rhesus monkey endometrium during the menstrual cycle (day -6 to day +10) and pre-implantation stages (day +3 to day +6) of gestation, with day 0 considered as the day of ovulation. Acid hydrolases exhibited low levels in proliferative phase endometria followed by their gradual rise in the secretory phase of the menstrual cycle. Despite no shifts in the levels of serum progesterone and estradiol-17 beta, the pre-implantation period was, however, associated with distinct changes in enzyme profiles characterized by lower absolute levels (P less than 0.05) of acid phosphatase and beta-glucuronidase on days 3 to 6 of gestation, whereas cathepsin D activity declined significantly (P less than 0.05) on days 5 and 6. Alkaline phosphatase showed a characteristic rise during the pre-ovulatory period with a gradual lowering of its level in post-ovulatory phase endometria of a non-fertile cycle; in contrast, during early gestation, alkaline phosphatase activity showed a marked elevation (P less than 0.05) on days 5 and 6 of gestation. The significance of these findings is discussed.
在恒河猴月经周期（第-6天至第+10天）和妊娠植入前阶段（第+3天至第+6天），以排卵日为第0天，研究了β-葡萄糖醛酸酶、组织蛋白酶D、酸性和碱性磷酸酶。酸性水解酶在增殖期子宫内膜中水平较低，随后在月经周期的分泌期逐渐升高。尽管血清孕酮和雌二醇-17β水平没有变化，但植入前期的酶谱有明显变化，其特征是在妊娠第3至6天酸性磷酸酶和β-葡萄糖醛酸酶的绝对水平较低（P<0.05），而组织蛋白酶D活性在第5天和第6天显著下降（P<0.05）。碱性磷酸酶在排卵前期有特征性升高，在未受孕周期的排卵后阶段子宫内膜中其水平逐渐降低；相反，在妊娠早期，碱性磷酸酶活性在妊娠第5天和第6天显著升高（P<0.05）。讨论了这些发现的意义。
