Germans Trias i Pujol Research Institute, Badalona, Spain.
FEBS J. 2022 May;289(10):2771-2792. doi: 10.1111/febs.15895. Epub 2021 May 7.
The histone deacetylases (HDACs) family of enzymes possess deacylase activity for histone and nonhistone proteins; HDAC11 is the latest discovered HDAC and the only member of class IV. Besides its shared HDAC family catalytical activity, recent studies underline HDAC11 as a multifaceted enzyme with a very efficient long-chain fatty acid deacylase activity, which has open a whole new field of action for this protein. Here, we summarize the importance of HDAC11 in a vast array of cellular pathways, which has been recently highlighted by discoveries about its subcellular localization, biochemical features, and its regulation by microRNAs and long noncoding RNAs, as well as its new targets and interactors. Additionally, we discuss the recent work showing the consequences of HDAC11 dysregulation in brain, skeletal muscle, and adipose tissue, and during regeneration in response to kidney, skeletal muscle, and vascular injuries, underscoring HDAC11 as an emerging hub protein with physiological functions that are much more extensive than previously thought, and with important implications in human diseases.
组蛋白去乙酰化酶（HDACs）家族的酶具有组蛋白和非组蛋白蛋白的脱乙酰酶活性；HDAC11 是最新发现的 HDAC，也是唯一属于 IV 类的成员。除了其共有的 HDAC 家族催化活性外，最近的研究强调 HDAC11 是一种具有非常高效长链脂肪酸脱乙酰酶活性的多功能酶，这为该蛋白开辟了一个全新的作用领域。在这里，我们总结了 HDAC11 在广泛的细胞途径中的重要性，最近的发现强调了其亚细胞定位、生化特征及其受 microRNAs 和长非编码 RNA 的调节，以及其新的靶标和相互作用物。此外，我们还讨论了最近的工作，这些工作表明 HDAC11 失调在大脑、骨骼肌和脂肪组织中的后果，以及在肾脏、骨骼肌和血管损伤后的再生中，突出了 HDAC11 作为一个新兴的枢纽蛋白，其生理功能比以前认为的要广泛得多，并对人类疾病具有重要意义。
