Laboratory of Drug Design and Discovery, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India.
Department of Pharmaceutical Technology, JIS University, 81, Nilgunj Road, Agarpara, Kolkata 700109, West Bengal, India.
Biochem Pharmacol. 2024 Jul;225:116312. doi: 10.1016/j.bcp.2024.116312. Epub 2024 May 22.
Histone deacetylase 11 (HDAC11), a member of the HDAC family, has emerged as a critical regulator in numerous physiological as well as pathological processes. Due to its diverse roles, HDAC11 has been a focal point of research in recent times. Different non-selective inhibitors are already approved, and research is going on to find selective HDAC11 inhibitors. The objective of this review is to comprehensively explore the role of HDAC11 as a pivotal regulator in a multitude of physiological and pathological processes. It aims to delve into the intricate details of HDAC11's structural and functional aspects, elucidating its molecular interactions and implications in different disease contexts. With a primary focus on elucidating the structure-activity relationships (SARs) of HDAC11 inhibitors, this review also aims to provide a holistic understanding of how its molecular architecture influences its inhibition. Additionally, by integrating both established knowledge and recent research, the review seeks to contribute novel insights into the potential therapeutic applications of HDAC11 inhibitors. Overall, the scope of this review spans from fundamental research elucidating the complexities of HDAC11 biology to the potential of targeting HDAC11 in therapeutic interventions.
组蛋白去乙酰化酶 11（HDAC11）是 HDAC 家族的成员，已成为众多生理和病理过程的关键调节因子。由于其多种作用，HDAC11 一直是近期研究的焦点。已经有不同的非选择性抑制剂获得批准，并且正在研究选择性 HDAC11 抑制剂。本综述的目的是全面探讨 HDAC11 作为多种生理和病理过程关键调节因子的作用。它旨在深入研究 HDAC11 的结构和功能方面的复杂细节，阐明其在不同疾病背景下的分子相互作用和影响。本综述主要侧重于阐明 HDAC11 抑制剂的结构-活性关系（SAR），还旨在全面了解其分子结构如何影响其抑制作用。此外，通过整合已建立的知识和最近的研究，该综述旨在为 HDAC11 抑制剂的潜在治疗应用提供新的见解。总的来说，本综述的范围从阐明 HDAC11 生物学复杂性的基础研究到靶向 HDAC11 进行治疗干预的潜力。
