Clinic for Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Freiburg, Germany.
Seattle, Washington, USA.
Biol Psychol. 2021 May;162:108096. doi: 10.1016/j.biopsycho.2021.108096. Epub 2021 Apr 20.
Recent trends in literature, along with the changes to the Diagnostic and Statistical Manual (DSM), make it imperative to study Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) together, in order to better understand potential aetiological commonalities between these highly comorbid disorders. The present study examines social cueing, a highly studied construct in ASD, and intra-subject variability (ISV), a potential endophenotype of ADHD, in four groups of typically developing (TD), ADHD, ASD- (ASD without ADHD), ASD+ (ASD with ADHD) participants (N = 85) aged 10-13 years. Results showed that social cueing is intact in the 'pure' ASD group when task expectations are clear. The ADHD group showed faster saccadic reaction times, no increased ISV and a pattern of viewing comparable to the TD group. However, the ASD + group showed a differences in processing style and ISV. A secondary analysis gives evidence of non-additive effects of the ASD and ADHD factors.
近年来，文献研究趋势以及《精神疾病诊断与统计手册》（DSM）的变化，使得有必要将注意力缺陷多动障碍（ADHD）和自闭症谱系障碍（ASD）一起进行研究，以便更好地理解这两种高度共病障碍之间潜在的病因共性。本研究在 10-13 岁的四组典型发育（TD）、ADHD、ASD-（无 ADHD 的 ASD）、ASD+（有 ADHD 的 ASD）参与者中检查了社会线索，这是一种在 ASD 中得到高度研究的结构，以及个体内变异性（ISV），这是 ADHD 的一个潜在的内表型。结果表明，当任务期望明确时，“纯”ASD 组的社会线索是完整的。ADHD 组的眼跳反应时间更快，ISV 没有增加，并且观察模式与 TD 组相似。然而，ASD+组在处理方式和 ISV 上存在差异。二次分析提供了 ASD 和 ADHD 因素非加性效应的证据。
