Groom Madeleine J, Kochhar Puja, Hamilton Antonia, Liddle Elizabeth B, Simeou Marina, Hollis Chris
Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Innovation Park, Triumph Road, Nottingham, NG7 2TU, UK.
Derbyshire Healthcare NHS Foundation Trust, Temple House, Mill Hill Lane, Derby, DE23 6SA, UK.
J Autism Dev Disord. 2017 May;47(5):1496-1509. doi: 10.1007/s10803-017-3078-4.
This study investigated the neurobiological basis of comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). We compared children with ASD, ADHD or ADHD+ASD and typically developing controls (CTRL) on behavioural and electrophysiological correlates of gaze cue and face processing. We measured effects of ASD, ADHD and their interaction on the EDAN, an ERP marker of orienting visual attention towards a spatially cued location and the N170, a right-hemisphere lateralised ERP linked to face processing. We identified atypical gaze cue and face processing in children with ASD and ADHD+ASD compared with the ADHD and CTRL groups. The findings indicate a neurobiological basis for the presence of comorbid ASD symptoms in ADHD. Further research using larger samples is needed.
本研究调查了自闭症谱系障碍（ASD）与注意力缺陷多动障碍（ADHD）共病的神经生物学基础。我们比较了患有ASD、ADHD或ADHD+ASD的儿童以及发育正常的对照组（CTRL）在注视线索和面部加工的行为及电生理相关性方面的差异。我们测量了ASD、ADHD及其相互作用对EDAN（一种将视觉注意力导向空间线索位置的ERP标记物）和N170（一种与面部加工相关的右侧半球偏侧化ERP）的影响。与ADHD组和CTRL组相比，我们发现ASD组和ADHD+ASD组儿童存在非典型的注视线索和面部加工。这些发现表明ADHD中共病ASD症状存在神经生物学基础。需要使用更大样本进行进一步研究。
