Center of Nanoscience, Nanotechnology and Innovation - CeNano(2)I, Department of Metallurgical and Materials Engineering, Federal University of Minas Gerais - UFMG, Av. Antônio Carlos, 6627 Belo Horizonte/M.G., Brazil.
Center of Nanoscience, Nanotechnology and Innovation - CeNano(2)I, Department of Metallurgical and Materials Engineering, Federal University of Minas Gerais - UFMG, Av. Antônio Carlos, 6627 Belo Horizonte/M.G., Brazil.
Int J Biol Macromol. 2021 Jul 1;182:1091-1111. doi: 10.1016/j.ijbiomac.2021.04.116. Epub 2021 Apr 21.
Acute or chronic brain injuries promote deaths and the life-long debilitating neurological status where, despite advances in therapeutic strategies, clinical outcome hardly achieves total patient recovery. In recent decades, brain tissue engineering emerged as an encouraging area of research for helping in damaged central nervous system (CNS) recovery. Polysaccharides are abundant naturally occurring biomacromolecules with a great potential enhancement of advanced technologies in brain tissue repair and regeneration (BTRR). Besides carrying rich biological information, polysaccharides can interact and communicate with biomolecules, including glycosaminoglycans present in cell membranes and many signaling moieties, growth factors, chemokines, and axon guidance molecules. This review includes a comprehensive investigation of the current progress on designing and developing polysaccharide-based soft matter biomaterials for BTRR. Although few interesting reviews concerning BTRR have been reported, this is the first report specifically focusing on covering multiple polysaccharides and polysaccharide-based functionalized biomacromolecules in this emerging and intriguing field of multidisciplinary knowledge. This review aims to cover the state of art challenges and prospects of this fascinating field while presenting the richness of possibilities of using these natural biomacromolecules for advanced biomaterials in prospective neural tissue engineering applications.
急性或慢性脑损伤会导致死亡和终身神经功能障碍，尽管治疗策略有所进步，但临床结果几乎无法使患者完全康复。近几十年来，脑组织工程作为一个令人鼓舞的研究领域出现，有助于受损中枢神经系统 (CNS) 的恢复。多糖是丰富的天然存在的生物大分子，具有增强先进的脑组织修复和再生 (BTRR) 技术的巨大潜力。除了携带丰富的生物信息外，多糖还可以与生物分子相互作用和交流，包括细胞膜中的糖胺聚糖和许多信号分子、生长因子、趋化因子和轴突导向分子。本综述包括对用于 BTRR 的多糖基软物质生物材料的设计和开发的最新进展的全面调查。尽管已经报道了一些关于 BTRR 的有趣评论，但这是第一篇专门针对多聚糖和多糖基功能化生物大分子的综述，涵盖了这个多学科知识的新兴和有趣领域。本综述旨在介绍这个迷人领域的现状挑战和前景，同时展示使用这些天然生物大分子用于先进生物材料在未来神经组织工程应用中的丰富可能性。
