Center of Scientific Research, Chengdu Medical College, Chengdu, Sichuan 610500, PR China; Laboratory of Plastic Surgery and Burns, Department of Plastic Surgery and Burns, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, PR China.
Carbohydr Polym. 2022 Feb 15;278:118952. doi: 10.1016/j.carbpol.2021.118952. Epub 2021 Nov 30.
Polysaccharide hydrogels have been widely utilized in tissue engineering. They interact with the organismal environments, modulating the cargos release and realizing of long-term survival and activations of living cells. In this review, the potential strategies for modification of polysaccharides were introduced firstly. It is not only used to functionalize the polysaccharides for the consequent formation of hydrogels, but also used to introduce versatile side groups for the regulation of cell behavior. Then, techniques and underlying mechanisms in inducing the formation of hydrogels by polysaccharides or their derivatives are briefly summarized. Finally, the applications of polysaccharide hydrogels in vivo, mainly focus on the performance for alleviation of foreign-body response (FBR) and as cell scaffolds for tissue regeneration, are exemplified. In addition, the perspectives and challenges for further research are addressed. It aims to provide a comprehensive framework about the potentials and challenges that the polysaccharide hydrogels confronting in tissue engineering.
多糖水凝胶在组织工程中得到了广泛的应用。它们与机体环境相互作用，调节载体的释放，实现活细胞的长期存活和激活。在这篇综述中，首先介绍了多糖修饰的潜在策略。它不仅用于多糖的功能化，从而形成水凝胶，还用于引入多功能侧基来调节细胞行为。然后，简要总结了通过多糖或其衍生物诱导水凝胶形成的技术和潜在机制。最后，举例说明了多糖水凝胶在体内的应用，主要集中在减轻异物反应（FBR）和作为组织再生的细胞支架的性能上。此外，还讨论了进一步研究的前景和挑战。本文旨在提供一个关于多糖水凝胶在组织工程中面临的潜力和挑战的全面框架。
