Petersen N E, Elmgreen J, Teisner B, Svehag S E
Institute of Medical Microbiology, University of Odense, Denmark.
Acta Med Scand. 1988;223(6):557-60.
Split products of complement component 3 (C3) and complement component 4 (C4) derived from activation of the alternative and classical complement pathways were measured in untreated outpatients, 20 with Crohn's disease and 19 with rheumatoid arthritis. Elevated levels of the d split product of C4 (C4d) were observed in 12 of 19 patients with rheumatoid arthritis and in 9 of 20 patients with Crohn's disease. Levels of the d split product of C3 (C3d) were increased in 14 of 19 patients with rheumatoid arthritis and in 6 of 20 Crohn's disease patients. The median values of C4d and C3d were significantly increased in both groups of patients. C3d concentrations correlated positively with C4d levels (rs = 0.51-0.56, p less than 0.005). The complement activation was not reflected in reduced plasma levels of native C3 and C4. The data indicate activation of the classical complement pathway in both rheumatoid arthritis and Crohn's disease.
在未经治疗的门诊患者中，对20例克罗恩病患者和19例类风湿关节炎患者检测了源自替代补体途径和经典补体途径激活的补体成分3（C3）和补体成分4（C4）的裂解产物。在19例类风湿关节炎患者中有12例以及20例克罗恩病患者中有9例观察到C4的d裂解产物（C4d）水平升高。在19例类风湿关节炎患者中有14例以及20例克罗恩病患者中有6例C3的d裂解产物（C3d）水平升高。两组患者中C4d和C3d的中位数均显著升高。C3d浓度与C4d水平呈正相关（rs = 0.51 - 0.56，p小于0.005）。补体激活并未表现为天然C3和C4血浆水平降低。数据表明类风湿关节炎和克罗恩病中经典补体途径均被激活。
