冰片抗脑缺血作用及其机制研究
Study on the anti-cerebral ischemia effect of borneol and its mechanism.
作者信息
Kong Qing-xia, Wu Zhao-ying, Chu Xu, Liang Ru-qing, Xia Min, Li Lei
机构信息
Department of Neurology, Affiliated Hospital of Shan'dong Ji'ning Medical College, China; 272129.
出版信息
Afr J Tradit Complement Altern Med. 2013 Nov 2;11(1):161-4. doi: 10.4314/ajtcam.v11i1.25. eCollection 2014.
BACKGROUND
Borneol is the processed item from resin of Dryobalanops aromatica Gaertn. f. It can enhance the activity of antioxidant enzymes in brain tissue and reduce inflammatory response by improving the energy metabolism of ischemic brain regions, and thereby reduces brain tissue damage. The objective of this paper was to study the anti-cerebral ischemia effect of borneol and its mechanism.
MATERIALS AND METHODS
The anti-cerebral ischemia effect of borneol was studied by ligation of bilateral common carotid arteries (CCA), and vagus nerves in mice and the acute cerebral ischemia-reperfusion experiment in rats.
RESULTS
Compared with the blank and solvent control groups, the borneol low-; medium-; and high-dose groups can significantly prolong the gasping time of mice after decapitation, and extend the survival time of mice after ligation of bilateral CCA, and vagus nerves.
CONCLUSION
Compared with the Xueshuantong injection group, the prolongation of survival time of mice after ligation of bilateral CCA, and vagus nerves was more apparent in the high-dose borneol experimental group; each experimental group can significantly reduce the number of leukocyte infiltration, the number of ICAM-1-positive vessels, as well as the number of TNF-α-positive cells.
CONCLUSION
Borneol has an anti-cerebral ischemia effect.
背景
冰片是龙脑香树脂的加工品。它可增强脑组织中抗氧化酶的活性，通过改善缺血脑区的能量代谢来减轻炎症反应，从而减轻脑组织损伤。本文旨在研究冰片的抗脑缺血作用及其机制。
材料与方法
通过结扎小鼠双侧颈总动脉（CCA）和迷走神经以及大鼠急性脑缺血再灌注实验来研究冰片的抗脑缺血作用。
结果
与空白对照组和溶剂对照组相比，冰片低、中、高剂量组均可显著延长小鼠断头后的喘息时间，并延长小鼠双侧CCA和迷走神经结扎后的存活时间。
结论
与血栓通注射液组相比，高剂量冰片实验组小鼠双侧CCA和迷走神经结扎后存活时间的延长更明显；各实验组均可显著减少白细胞浸润数量、ICAM-1阳性血管数量以及TNF-α阳性细胞数量。
结论
冰片具有抗脑缺血作用。
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