UCIBIO, REQUIMTE, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
UCIBIO, REQUIMTE, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Drug Discov Today. 2021 Oct;26(10):2397-2405. doi: 10.1016/j.drudis.2021.04.012. Epub 2021 Apr 20.
The ability of some hydrogels to exhibit a phase transition or change their structure in response to stimuli has been extensively explored for drug depot formation and controlled drug release. Taking advantage of the unique features of the tumor microenvironment (TME) or externally applied triggers, several injectable stimuli-responsive hydrogels have been described as promising candidates for intratumoral drug delivery. In this review, we provide a brief overview of the TME and highlight the advantages of intratumoral administration, followed by a summary of the reported strategies to endow hydrogels with responsiveness to physical (temperature and light), chemical (pH and redox potential), or biological (enzyme) stimuli.
一些水凝胶能够响应刺激表现出相转变或改变其结构，这一特性已被广泛探索用于药物库形成和控制药物释放。利用肿瘤微环境（TME）或外部施加的触发因素的独特特征，几种可注射的刺激响应水凝胶已被描述为用于肿瘤内药物递送的有前途的候选物。在这篇综述中，我们简要概述了 TME，并强调了肿瘤内给药的优势，随后总结了赋予水凝胶对物理（温度和光）、化学（pH 和氧化还原电位）或生物（酶）刺激响应的报道策略。
