Institute of Pharmacy & Pharmacology, School of Pharmaceutical Science, University of South China, Hengyang, 410001, China.
Macromol Rapid Commun. 2022 May;43(10):e2200007. doi: 10.1002/marc.202200007. Epub 2022 Apr 10.
The stimuli-responsiveness of injectable hydrogel has been drastically developed for the controlled release of drugs and has achieved encouraging curative effects in a variety of diseases including wounds, cardiovascular diseases, and tumors. The gelation, swelling, and degradation of such hydrogels respond to endogenous biochemical factors (such as pH, reactive oxygen species, glutathione, enzymes, glucose) and/or to exogenous physical stimulations (like light, magnetism, electricity, and ultrasound), thereby accurately releasing loaded drugs in response to specifically pathological status and as desired for treatment plan, and thus improving therapeutic efficacy effectively. This paper gives a detailed introduction of recent progresses in responsive injectable hydrogels and focuses on the design strategy of various stimuli-sensitivities and their resultant alteration of gel dissociation and drug liberation behavior. Their application in disease treatment is also discussed.
可注射水凝胶的刺激响应性得到了极大的发展，可用于控制药物的释放，并在包括伤口、心血管疾病和肿瘤在内的多种疾病中取得了令人鼓舞的治疗效果。此类水凝胶的凝胶化、溶胀和降解响应内源性生化因素（如 pH 值、活性氧、谷胱甘肽、酶、葡萄糖）和/或外源性物理刺激（如光、磁、电和超声），从而根据特定的病理状态和治疗计划的要求精确释放负载药物，从而有效提高治疗效果。本文详细介绍了响应性可注射水凝胶的最新进展，并重点介绍了各种刺激敏感性的设计策略及其对凝胶解离和药物释放行为的改变。还讨论了它们在疾病治疗中的应用。
