Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania.
Division of Pediatric Endocrinology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania.
Ann Allergy Asthma Immunol. 2021 Aug;127(2):236-242.e1. doi: 10.1016/j.anai.2021.04.013. Epub 2021 Apr 20.
Age- and sex-related differences in asthma may be due to changes in sex hormone levels.
To evaluate whether a change in free testosterone or free testosterone-to-estradiol ratio is associated with changes in lung function and eosinophils in the Puerto Rican youth.
We tested for the association between the change in sex hormone levels and change in lung function or change in eosinophils in a prospective study of 317 children (with and without asthma) followed up from ages 6 to 14 years to ages 10 to 20 years (146 females, 171 males) in San Juan, Puerto Rico. Serum levels of testosterone, estradiol, sex hormone-binding globulin, and progesterone were measured at 2 study visits, approximately 4.9 years apart. Using testosterone and sex hormone-binding globulin levels, we derived free testosterone and the free testosterone-to-estradiol ratio. Multivariable linear regression was used for the analysis of change in lung function and eosinophils, conducted separately by sex.
In girls, each quartile increment in the free testosterone-to-estradiol ratio was associated with a 2.03% increment in percent predicted forced expiratory volume in 1 second (FEV)/forced vital capacity (FVC) between study visits. In males, each quartile increment in the free testosterone-to-estradiol ratio was associated with a 3.27% increment in percent predicted FEV and a 1.81% increment in percent predicted FEV/FVC between study visits. In girls with asthma, an increased free testosterone-to-estradiol ratio was significantly associated with decreased eosinophils between visits (P=0.03).
In Puerto Rican youth, increased free testosterone-to-estradiol ratio over time was associated with an increased FEV/FVC in both sexes, and with an increased FEV in males.
哮喘的年龄和性别差异可能与性激素水平的变化有关。
评估游离睾酮或游离睾酮与雌二醇比值的变化是否与波多黎各青少年的肺功能和嗜酸性粒细胞变化有关。
我们在一项前瞻性研究中检测了 317 名儿童（有无哮喘）的性激素水平变化与肺功能或嗜酸性粒细胞变化之间的关系，这些儿童从 6 岁到 14 岁随访到 10 岁到 20 岁（146 名女性，171 名男性），地点在波多黎各圣胡安。在两次研究访视中测量了睾酮、雌二醇、性激素结合球蛋白和孕酮的血清水平，两次访视间隔约 4.9 年。使用睾酮和性激素结合球蛋白水平，我们得出了游离睾酮和游离睾酮与雌二醇的比值。采用多元线性回归分析分别按性别分析肺功能和嗜酸性粒细胞的变化。
在女孩中，游离睾酮与雌二醇比值每增加一个四分位间距，研究访视之间的预计 1 秒用力呼气量（FEV）/用力肺活量（FVC）百分比增加 2.03%。在男性中，游离睾酮与雌二醇比值每增加一个四分位间距，研究访视之间的预计 FEV 百分比增加 3.27%，预计 FEV/FVC 百分比增加 1.81%。在患有哮喘的女孩中，游离睾酮与雌二醇比值的增加与两次访视之间的嗜酸性粒细胞减少显著相关（P=0.03）。
在波多黎各青少年中，随着时间的推移，游离睾酮与雌二醇比值的增加与两性的 FEV/FVC 增加以及男性的 FEV 增加有关。
