Abdollahi Nejat Mazyar, Klaassen Remco V, Spijker Sabine, Smit August B
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Curr Opin Pharmacol. 2021 Jun;58:52-61. doi: 10.1016/j.coph.2021.03.001. Epub 2021 Apr 21.
AMPA receptors mediate fast synaptic transmission in the CNS and can assemble with several types of auxiliary proteins in a spatio-temporal manner, from newly synthesized AMPA receptor tetramers to mature AMPA receptors in the cell membrane. As such, the interaction of auxiliary subunits with the AMPA receptor plays a major role in the regulation of AMPA receptor biogenesis, trafficking, and biophysical properties. Throughout the years, various 'families' of proteins have been identified and today the approximate full complement of AMPAR auxiliary proteins is known. This review presents the current knowledge on the most prominent AMPA-receptor-interacting auxiliary proteins, highlights recent results regarding the Shisa protein family, and provides a discussion on future research that might contribute to the discovery of novel pharmacological targets of auxiliary subunits.
AMPA 受体介导中枢神经系统中的快速突触传递，并且能够以时空方式与几种类型的辅助蛋白组装，从新合成的AMPA受体四聚体到细胞膜中的成熟AMPA受体。因此，辅助亚基与AMPA受体的相互作用在AMPA受体生物发生、转运和生物物理特性的调节中起主要作用。多年来，已经鉴定出各种蛋白质“家族”，如今已知AMPA受体辅助蛋白的大致完整组成。本综述介绍了目前关于最突出的与AMPA受体相互作用的辅助蛋白的知识，强调了关于Shisa蛋白家族的最新研究结果，并对未来可能有助于发现辅助亚基新药理学靶点的研究进行了讨论。
