Clinical Efficacy of Two Topical Agents for the Remineralization of Enamel White Spot Lesions in Primary Teeth.

The purpose of this study was to compare the remineralizing clinical efficacy of fluoride plus hydroxyapatite (Remin Pro®; RP) and fluoride plus casein phosphopeptide-amorphous calcium phosphate fluoride (Mi Paste Plus®; MPP) for the treatment of white spot lesions (WSLs) in primary tooth enamel. This study was a randomized double-blind clinical trial. It included patients with at least one primary maxillary anterior tooth with a WSL on the enamel surface. They were randomly assigned to receive either the twice-daily at-home topical application of RP or MPP or fluoride (NaF) paste (Colgate Total®; CT). The remineralization degree was quantified by the change in the number of units of fluorescence (UF) measured with laser fluorescence pen device (DIAGNOdent™) from the baseline and at days 10 and 21. UF decreased significantly in all groups (P<0.001). Both RP and MPP resulted in significantly higher standardized mean difference (SMD) UF than CT (P<0.05); however, the difference between RP and MPP was not statistically significant (P>0.05). Topical application of Colgate Total®, Mi Paste Plus®, and Remin Pro® resulted in a remineralizing effect against white spot lesions on primary tooth enamel. Both MPP and RP were statistically superior to CT.