Dr. Vicente Esparza-Villalpando is an associate professor, Pediatric Dentistry Postgraduate Program, Faculty of Dentistry, San Luis Potosí University, San Luis Potosí, San Luis Potosí, Mexico.
Dr. Edy Fernandez-Hernandez is a resident, Pediatric Dentistry Postgraduate Program, Faculty of Dentistry, San Luis Potosí University, San Luis Potosí, San Luis Potosí, Mexico.
Pediatr Dent. 2021 Mar 15;43(2):95-101.
The purpose of this study was to compare the remineralizing clinical efficacy of fluoride plus hydroxyapatite (Remin Pro®; RP) and fluoride plus casein phosphopeptide-amorphous calcium phosphate fluoride (Mi Paste Plus®; MPP) for the treatment of white spot lesions (WSLs) in primary tooth enamel. This study was a randomized double-blind clinical trial. It included patients with at least one primary maxillary anterior tooth with a WSL on the enamel surface. They were randomly assigned to receive either the twice-daily at-home topical application of RP or MPP or fluoride (NaF) paste (Colgate Total®; CT). The remineralization degree was quantified by the change in the number of units of fluorescence (UF) measured with laser fluorescence pen device (DIAGNOdent™) from the baseline and at days 10 and 21. UF decreased significantly in all groups (P<0.001). Both RP and MPP resulted in significantly higher standardized mean difference (SMD) UF than CT (P<0.05); however, the difference between RP and MPP was not statistically significant (P>0.05). Topical application of Colgate Total®, Mi Paste Plus®, and Remin Pro® resulted in a remineralizing effect against white spot lesions on primary tooth enamel. Both MPP and RP were statistically superior to CT.
本研究旨在比较氟化物加羟基磷灰石（Remin Pro®；RP）和氟化物加酪蛋白磷酸肽-无定形磷酸钙氟化物（Mi Paste Plus®；MPP）治疗乳牙釉质白斑（WSL）的再矿化临床疗效。这是一项随机双盲临床试验。纳入了至少有一颗上颌前牙釉面有 WSL 的患者。他们被随机分配接受 RP 或 MPP 或氟化物（NaF）糊剂（Colgate Total®；CT）的每日两次家庭局部应用。使用激光荧光笔设备（DIAGNOdent™）测量荧光单位（UF）的变化来量化再矿化程度，从基线和第 10 天和第 21 天进行测量。所有组的 UF 均显著降低（P<0.001）。RP 和 MPP 均导致 UF 的标准化均数差（SMD）显著高于 CT（P<0.05）；然而，RP 和 MPP 之间的差异无统计学意义（P>0.05）。Colgate Total®、Mi Paste Plus®和 Remin Pro®的局部应用对乳牙釉质白斑具有再矿化作用。MPP 和 RP 在统计学上均优于 CT。
