Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Spitalgasse 23, Vienna, 1090, Austria.
Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, Vienna, 1090, Austria.
Sci Rep. 2021 Apr 23;11(1):8838. doi: 10.1038/s41598-021-86848-1.
A prototype of a navigation system to fuse two image modalities is presented. The standard inter-modality registration is replaced with a tracker-based image registration of calibrated imaging devices. Intra-procedure transrectal US (TRUS) images were merged with pre-procedure magnetic resonance (MR) images for prostate biopsy. The registration between MR and TRUS images was performed by an additional abdominal 3D-US (ab-3D-US), which enables replacing the inter-modal MR/TRUS registration by an intra-modal ab-3D-US/3D-TRUS registration. Calibration procedures were carried out using an optical tracking system (OTS) for the pre-procedure image fusion of the ab-3D-US with the MR. Inter-modal ab-3D-US/MR image fusion was evaluated using a multi-cone phantom for the target registration error (TRE) and a prostate phantom for the Dice score and the Hausdorff distance of lesions . Finally, the pre-procedure ab- 3D-US was registered with the TRUS images and the errors for the transformation from the MR to the TRUS were determined. The TRE of the ab-3D-US/MR image registration was 1.81 mm. The Dice-score and the Hausdorff distance for ab-3D-US and MR were found to be 0.67 and 3.19 mm. The Dice score and the Hausdorff distance for TRUS and MR were 0.67 and 3.18 mm. The hybrid navigation system showed sufficient accuracy for fusion guided biopsy procedures with prostate phantoms. The system might provide intra-procedure fusion for most US-guided biopsy and ablation interventions.
提出了一种融合两种图像模态的导航系统原型。标准的模态间配准被基于跟踪器的校准成像设备的图像配准所取代。经直肠超声（TRUS）图像在前列腺活检前与磁共振（MR）图像融合。MR 和 TRUS 图像之间的配准通过附加的腹部 3D-US（ab-3D-US）完成，这使得可以用模态内 ab-3D-US/3D-TRUS 配准代替模态间 MR/TRUS 配准。使用光学跟踪系统（OTS）进行了校准程序，以实现 ab-3D-US 与 MR 的预配准图像融合。使用多锥体模体评估了模态间 ab-3D-US/MR 图像融合的靶标配准误差（TRE），并使用前列腺模体评估了病变的 Dice 评分和 Hausdorff 距离。最后，将预处理的 ab-3D-US 与 TRUS 图像配准，并确定从 MR 到 TRUS 的转换误差。ab-3D-US/MR 图像配准的 TRE 为 1.81mm。ab-3D-US 和 MR 的 Dice 评分和 Hausdorff 距离分别为 0.67 和 3.19mm。TRUS 和 MR 的 Dice 评分和 Hausdorff 距离分别为 0.67 和 3.18mm。混合导航系统在具有前列腺模体的融合引导活检程序中显示出足够的准确性。该系统可能为大多数超声引导活检和消融干预提供术中融合。
