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草甘膦在细菌产生抗微生物药物耐药性中的作用?

Role of glyphosate in the emergence of antimicrobial resistance in bacteria?

机构信息

Institut Hospitalo-universitaire Méditerranée Infection, Marseille, France.

Aix Marseille Université, Institut de Recherche pour le Développement (IRD), Assistance Publique-Hôpitaux de Marseille (APHM), Microbes Evolution Phylogénie et Infections (MEPHI), Marseille, France.

出版信息

J Antimicrob Chemother. 2021 Jun 18;76(7):1655-1657. doi: 10.1093/jac/dkab102.

DOI:10.1093/jac/dkab102
PMID:33893490
Abstract

There is a discrepancy between antibiotic use in medicine and agriculture in the intertropical zone and frequency of antibiotic resistance in clinical bacteria in these countries. We provide evidence that glyphosate (a herbicide but also an antibiotic drug) could be a possible driver of antibiotic resistance in countries where this herbicide is widely used because of modification of the microbial environment. Emergence of resistance in bacteria and fungi is correlated with glyphosate use in the world over the last 40 years.

摘要

在热带地区,医学和农业领域的抗生素使用情况与这些国家临床细菌中的抗生素耐药频率存在差异。我们提供的证据表明,由于微生物环境的改变,草甘膦(一种除草剂,但也是一种抗生素药物)可能是导致这些除草剂广泛使用的国家出现抗生素耐药的一个因素。在过去的 40 年中,世界范围内细菌和真菌耐药性的出现与草甘膦的使用有关。

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Role of glyphosate in the emergence of antimicrobial resistance in bacteria?草甘膦在细菌产生抗微生物药物耐药性中的作用?
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引用本文的文献

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J Environ Qual. 2025 Jan-Feb;54(1):160-180. doi: 10.1002/jeq2.20655. Epub 2024 Nov 25.
2
Glyphosate affects persistence and tolerance but not antibiotic resistance.草甘膦影响持久性和耐受性但不影响抗生素耐药性。
BMC Microbiol. 2023 Mar 7;23(1):61. doi: 10.1186/s12866-023-02804-1.
3
Treatment with Glyphosate Induces Tolerance of Citrus Pathogens to Glyphosate and Fungicides but Not to 1,8-Cineole.
草甘膦处理诱导柑橘病原菌对草甘膦和杀真菌剂的耐受性,但对 1,8-桉树脑无耐受性。
Molecules. 2022 Nov 28;27(23):8300. doi: 10.3390/molecules27238300.
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Glyphosate and glyphosate-based herbicides (GBHs) induce phenotypic imipenem resistance in Pseudomonas aeruginosa.草甘膦和草甘膦类除草剂(GBHs)诱导铜绿假单胞菌产生表型亚胺培南耐药性。
Sci Rep. 2022 Oct 29;12(1):18258. doi: 10.1038/s41598-022-23117-9.
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Life (Basel). 2022 May 9;12(5):707. doi: 10.3390/life12050707.
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