Steele R W, Crosby D L, Steele R W, Pilkington N S, Charlton R K
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock.
Am J Med Sci. 1988 Jun;295(6):503-6. doi: 10.1097/00000441-198806000-00002.
Ribavirin, a broad spectrum antiviral agent, has been shown to exhibit immunosuppressive activity. This property has raised concerns during clinical trials because candidates for antiviral therapy are those who may develop secondary bacterial infection. We therefore investigated a number of parameters of neutrophil function after the in vitro addition of various concentrations of ribavirin. At pharmacologic concentrations (1.25-7.5 micrograms/mL), percent killing of phagocytized bacteria was increased as measured by an acridine orange fluorochrome microassay, significantly higher at a concentration of 5 micrograms/mL (p less than .02). There was no concomitant adverse effect on adherence, random migration, chemotaxis, opsonization or phagocytosis. The present data indicate that ribavirin has no acute suppressive effect on granulocyte function and may even enhance bacterial killing capabilities for treated patients.
利巴韦林是一种广谱抗病毒药物，已被证明具有免疫抑制活性。在临床试验期间，这一特性引发了人们的担忧，因为抗病毒治疗的候选对象是那些可能发生继发性细菌感染的患者。因此，我们在体外添加不同浓度的利巴韦林后，研究了中性粒细胞功能的多个参数。在药理浓度（1.25 - 7.5微克/毫升）下，通过吖啶橙荧光染料微量测定法测得吞噬细菌的杀灭百分比有所增加，在浓度为5微克/毫升时显著更高（p小于0.02）。对黏附、随机迁移、趋化性、调理作用或吞噬作用没有伴随的不良影响。目前的数据表明，利巴韦林对粒细胞功能没有急性抑制作用，甚至可能增强治疗患者的细菌杀灭能力。
