酒精对人多形核白细胞趋化性、黏附性及吞噬作用的影响。

Effect of alcohol on chemotaxis, adherence and phagocytosis of human polymorphonuclear leucocytes.

作者信息

Hallengren B, Forsgren A

出版信息

Acta Med Scand. 1978;204(1-2):43-8. doi: 10.1111/j.0954-6820.1978.tb08396.x.

DOI:10.1111/j.0954-6820.1978.tb08396.x

Abstract

In view of the presumed increased susceptibility of chronic alcoholics to infectious diseases, the influence of alcohol in vitro on leucocyte adherence, neutrophil chemotaxis, phagocytosis and intracellular killing was investigated with highly standardized methods. A significant inhibitory influence on these leucocyte functions was found only at alcohol concentrations in excess of those obtained clinically. An interesting observation not reported before was increased adherence, phagocytosis and chemotaxis at low to moderate concentrations of alcohol.

摘要

鉴于推测慢性酗酒者对传染病的易感性增加，我们采用高度标准化的方法研究了酒精在体外对白细胞黏附、中性粒细胞趋化性、吞噬作用和细胞内杀伤的影响。仅在酒精浓度超过临床所达到的浓度时，才发现对这些白细胞功能有显著的抑制作用。一个以前未报道过的有趣观察结果是，在低至中等浓度的酒精作用下，黏附、吞噬作用和趋化性增加。