Corberand J X, Laharrague P F, Fillola G
Central Laboratory of Haematology, CHU Rangueil, Toulouse, France.
Alcohol Clin Exp Res. 1989 Aug;13(4):542-6. doi: 10.1111/j.1530-0277.1989.tb00374.x.
In an attempt to assess the effect of alcohol per se on human polymorphonuclear neutrophils (PMN), irrespective of other physiopathological parameters, we examined neutrophil function in healthy volunteers who had taken a single large dose of whisky. Before and at different times after ingestion, several PMN properties were simultaneously tested including random migration, in vitro chemotaxis, adherence, aggregation, cytochrome C reduction, phagocytosis, bacterial killing, intracellular cAMP and cGMP contents, myeloperoxidase, and neutrophil alkaline phosphatase scores. Only phagocytosis of Staphylococcus aureus was significantly depressed after alcohol ingestion. Adherence was inhibited only in some individuals when their respective blood alcohol levels were the highest. Both alterations were moderate and reversible. These data point out the limited effect of occasional alcohol consumption on the different facets of neutrophil behavior. These findings suggest that factors other than alcohol itself could be concerned in the marked PMN dysfunction well established in chronic alcoholism.
为了评估酒精本身对人类多形核中性粒细胞（PMN）的影响，而不考虑其他生理病理参数，我们检测了摄入一大剂量威士忌的健康志愿者的中性粒细胞功能。在摄入前及摄入后的不同时间，同时检测了几种PMN特性，包括随机迁移、体外趋化性、黏附、聚集、细胞色素C还原、吞噬作用、细菌杀伤、细胞内cAMP和cGMP含量、髓过氧化物酶以及中性粒细胞碱性磷酸酶评分。饮酒后仅金黄色葡萄球菌的吞噬作用显著降低。仅在一些个体血液酒精水平最高时黏附受到抑制。这两种改变都是中度且可逆的。这些数据表明偶尔饮酒对中性粒细胞行为不同方面的影响有限。这些发现提示，在慢性酒精中毒中已明确存在的明显PMN功能障碍可能涉及酒精本身以外的因素。
