Department of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, People's Republic of China.
Sleep Breath. 2022 Mar;26(1):167-188. doi: 10.1007/s11325-021-02384-2. Epub 2021 Apr 24.
The previous analysis of systematic reviews and meta-analyses have illustrated that obstructive sleep apnea (OSA) is correlated with multiple health outcomes. In the present research, our main aim was to execute an umbrella review to assess the available evidence for the associations between OSA and health outcomes.
Herein, a meta-analysis of previous observational investigations that have reported associations between OSA and health outcomes in all human populations and settings was performed. We used these studies to execute an umbrella review of available meta-analyses and systematic reviews.
Sixty-six articles comprising 136 unique outcomes were enrolled in this analysis. Of the 136 unique outcomes, 111 unique outcomes had significant associations (p < 0.05). Only 7 outcomes (coronary revascularization after PCI, postoperative respiratory failure, steatosis, alaninetrans aminase (ALT) elevation, metabolic syndrome (MS), psoriasis, and Parkinson's disease) had a high quality of evidence. Twenty-four outcomes had a moderate quality of evidence, and the remaining 80 outcomes had a weak quality of evidence. Sixty-nine outcomes exhibited significant heterogeneity. Twenty-five outcomes exhibited publication bias. Sixty-three (95%) studies showed critically low methodological quality.
Among the 66 meta-analyses exploring 136 unique outcomes, only 7 statistically significant outcomes were rated as high quality of evidence. OSA may correlate with an increased risk of coronary revascularization after PCI, postoperative respiratory failure, steatosis, ALT elevation, MS, psoriasis, and Parkinson's disease.
之前对系统评价和荟萃分析的分析表明，阻塞性睡眠呼吸暂停（OSA）与多种健康结果相关。在本研究中，我们的主要目的是进行伞式综述，以评估 OSA 与健康结果之间关联的现有证据。
在此，对之前报告了所有人群和环境中 OSA 与健康结果之间关联的观察性研究进行荟萃分析。我们使用这些研究来进行现有荟萃分析和系统评价的伞式综述。
共有 66 篇文章包含 136 个独特的结局被纳入本分析。在 136 个独特的结局中，有 111 个独特的结局具有显著关联（p<0.05）。只有 7 个结局（经皮冠状动脉介入治疗后冠状动脉血运重建、术后呼吸衰竭、脂肪变性、丙氨酸氨基转移酶（ALT）升高、代谢综合征（MS）、银屑病和帕金森病）具有高质量的证据。24 个结局具有中等质量的证据，其余 80 个结局具有低质量的证据。69 个结局表现出显著的异质性。25 个结局表现出发表偏倚。63（95%）项研究显示出严重的低方法学质量。
在 66 项探索 136 个独特结局的荟萃分析中，只有 7 个具有统计学意义的结局被评为高质量证据。OSA 可能与经皮冠状动脉介入治疗后冠状动脉血运重建、术后呼吸衰竭、脂肪变性、ALT 升高、MS、银屑病和帕金森病的风险增加相关。
