Chen Weiwei, Qian Wenqi, Zhong Lixian, Jing Gongwei
Department of Gastroenterology, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, China.
Department of Pharmacy, People's Hospital of Qiandongnan and Dong Autonomous Prefecture, Kaili, China.
Front Neurol. 2021 Dec 24;12:778062. doi: 10.3389/fneur.2021.778062. eCollection 2021.
An umbrella review was conducted for comprehensively evaluating previous review-based literature together with meta-analysis of observational investigations probing correlations between migraine and medical end-point ramifications in patients. The breadth and validity of these associations were assessed. Multiple online scientific repositories (including PubMed, Medline, Embase, and Web of Science) were investigated (inception-August 2021) for related meta-analyses focusing on links between migraine and all possible health/medical ramification end-points. A summary effect size and 95% CIs were determined for each identified study with such links. Heterogeneity and small-study influence traces were also evaluated. The AMSTAR 2 platform was employed for evaluating standards of methodology, together with objective criteria, for assessing the standards of datasets from each medical end-point scrutinized in this study. A total of 25 scientific reports comprising 10,237,230 participants for 49 meta-analyses of observational studies were selected. Among such 49 outcomes, 30 demonstrated statistical significance ( < 0.05). Significant associations were observed in multiple diseases, including cardiovascular/cerebrovascular, cerebral, pregnancy-related and metabolic disorders, other outcomes, and mortality. The results showed that migraine increased the risk of 29 health outcomes, though lowered the risk of breast cancer. However, evidence quality was graded as high only for angina. The evidence quality of ischaemic stroke, stroke, MACCE, WMAs, and asthma was graded as moderate. All remaining 24 outcomes had an evidence grade of "weak."
开展了一项伞状综述，以综合评估以往基于综述的文献，并对探讨偏头痛与患者医学终点后果之间相关性的观察性研究进行荟萃分析。评估了这些关联的广度和有效性。对多个在线科学数据库（包括PubMed、Medline、Embase和Web of Science）进行了调查（起始时间为2021年8月），以查找聚焦偏头痛与所有可能的健康/医学后果终点之间联系的相关荟萃分析。为每项识别出的有此类联系的研究确定了汇总效应量和95%置信区间。还评估了异质性和小研究影响痕迹。采用AMSTAR 2平台评估方法学标准以及客观标准，以评估本研究中审查的每个医学终点数据集的标准。共选择了25篇科学报告，包括针对49项观察性研究荟萃分析的10237230名参与者。在这49项结果中，30项具有统计学意义（<0.05）。在多种疾病中观察到显著关联，包括心血管/脑血管疾病、脑部疾病、妊娠相关疾病和代谢紊乱、其他结局以及死亡率。结果表明，偏头痛增加了29种健康结局的风险，不过降低了乳腺癌的风险。然而，证据质量仅对心绞痛被评为高等级。缺血性中风、中风、主要不良心血管和脑血管事件、白质病变以及哮喘的证据质量被评为中等。其余所有24项结局的证据等级为“低”。
