Institute for Nanotechnology Innovation, Department of Chemistry, Rhodes University, PO Box 94, Grahamstown, 6140, South Africa.
Photodiagnosis Photodyn Ther. 2021 Jun;34:102300. doi: 10.1016/j.pdpdt.2021.102300. Epub 2021 Apr 21.
Antimicrobial resistance is a most important problem facing the treatment of infectious diseases. Antimicrobial photodynamic therapy is an alternative treatment strategy, considered to be cost-effective and feasible. For this purpose, octa-imine substituted ZnPc (3) have been prepared and conjugated to nitrogen, sulfur co-doped graphene quantum dots (N,S-GQDs) through π-π stacking. The photophysical and photochemical properties of Pc alone and and Pc-conjugated to the GQD nanomaterial such as absorption, fluorescence, fluorescence life time, singlet oxygen quantum yields, triplet state quantum yields and exited state lifetimes were investigated in solutions before in vitro cell studies. The PACT activity of prepared structures was investigated against Gram-positive (Staphylococcus aureus). Our results suggest that the in the case of conjugation of zinc Pc to N,S-GQDs, photodynamic inactivation increased with the 100 % reduction percentage.
抗药性是治疗传染病所面临的最重要问题。抗菌光动力疗法是一种替代治疗策略，被认为具有成本效益和可行性。为此，制备了八亚甲基取代的锌酞菁（3），并通过π-π堆积将其共轭到氮、硫共掺杂石墨烯量子点（N，S-GQDs）上。在进行体外细胞研究之前，研究了卟啉单独和卟啉与 GQD 纳米材料共轭后的光物理和光化学性质，如吸收、荧光、荧光寿命、单线态氧量子产率、三重态量子产率和激发态寿命。针对革兰氏阳性菌（金黄色葡萄球菌），研究了制备结构的光激活细胞毒性（PACT）活性。我们的结果表明，在锌卟啉与 N，S-GQDs 共轭的情况下，光动力失活随着 100%减少百分比而增加。
