表面修饰的掺杂锌（II）酞菁的SiNPs增强的光动力抗菌活性：抗菌氨苄青霉素和来自磺内酯的额外电荷的影响。
Enhanced photodynamic antimicrobial activity of surface modified SiNPs doped with zinc(II) phthalocyanines: The effect of antimicrobial ampicillin and extra charges from a sultone.
作者信息
Magadla Aviwe, Nyokong Tebello
机构信息
Institute for Nanotechnology Innovation, Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa.
Institute for Nanotechnology Innovation, Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa.
出版信息
Photodiagnosis Photodyn Ther. 2020 Dec;32:101996. doi: 10.1016/j.pdpdt.2020.101996. Epub 2020 Sep 8.
1-(2-Methoxyethyl)piperidine sustituted Zn phthalocyanine complex (2) is synthesised and quartenised (3). These complexes are loaded into silica nanoparticles (SiNPs) that are futher surface modified with ampicillin and 1.3-propanesultone. The photophysical and photochemical properties of the complexes and their doped conjugates were investigated in dimethylsulfoxide. The cationic complex (3) is used for photodynamic antimicrobial activity. Log reduction values of above 9 are obtained towards the photoiactivation of Staphyloccocus aureus.
合成了1-(2-甲氧基乙基)哌啶取代的锌酞菁配合物(2)并进行了季铵化反应(3)。将这些配合物负载到二氧化硅纳米颗粒(SiNPs)中，并用氨苄青霉素和1,3-丙烷磺内酯对其进行进一步的表面修饰。在二甲基亚砜中研究了这些配合物及其掺杂共轭物的光物理和光化学性质。阳离子配合物(3)用于光动力抗菌活性研究。对金黄色葡萄球菌进行光活化处理后，对数减少值超过9。
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