环状 RNA 在胰腺癌中的多种作用。
The diverse roles of circular RNAs in pancreatic cancer.
机构信息
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
出版信息
Pharmacol Ther. 2021 Oct;226:107869. doi: 10.1016/j.pharmthera.2021.107869. Epub 2021 Apr 23.
Pancreatic cancer is one of the malignant tumors with poor prognosis. The molecular mechanisms of pancreatic oncogenesis and malignant progression are not fully elucidated. Several key signaling pathways, such as Notch, Wnt and hedgehog pathways, are important to drive pancreatic carcinogenesis. Recently, noncoding RNAs, especially circular RNAs (circRNAs), have been characterized to participate into pancreatic cancer development. Therefore, in this review article, we describe the association between circRNAs and pancreatic cancer prognosis. Moreover, we discuss how circRNAs are involved in regulation of cellular processes in pancreatic cancer, including proliferation, apoptosis, cell cycle, migration, invasion, EMT, metastasis, angiogenesis, drug resistance and immune escape. Furthermore, we mention that several compounds could regulate the expression of circRNAs, indicating that targeting circRNAs by compounds might be helpful for treating pancreatic cancer patients.
胰腺癌是预后较差的恶性肿瘤之一。胰腺癌发生和恶性进展的分子机制尚未完全阐明。几个关键的信号通路，如 Notch、Wnt 和 Hedgehog 通路，对驱动胰腺癌发生至关重要。最近，非编码 RNA，特别是环状 RNA（circRNA），被证实参与了胰腺癌的发生发展。因此，在这篇综述文章中，我们描述了 circRNA 与胰腺癌预后的关系。此外，我们还讨论了 circRNA 如何参与调控胰腺癌中的细胞过程，包括增殖、凋亡、细胞周期、迁移、侵袭、上皮间质转化、转移、血管生成、耐药和免疫逃逸。此外，我们提到了几种化合物可以调节 circRNA 的表达，表明通过化合物靶向 circRNA 可能有助于治疗胰腺癌患者。
Zotero 插件