Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea; Department of Biological Science, University of Ulsan, Ulsan, 44610, South Korea.
Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea.
Biochem Biophys Res Commun. 2021 Jun 18;558:44-50. doi: 10.1016/j.bbrc.2021.04.043. Epub 2021 Apr 22.
Sickness symptoms exerted via inflammatory responses occur in several infectious and chronic diseases. A growing body of evidence suggests that altered nutrient availability and metabolism are tightly coupled to inflammatory processes. However, the relationship between metabolic shifts and the development of the sickness response has not been explored fully. Therefore, we aimed to evaluate metabolic phenotypes with a mouse model showing sickness symptoms via systemic administration of lipopolysaccharide (LPS) in the present study. LPS injection elevated the lipid utilization and circulating levels of fatty acids. It also increased the levels of β-hydroxybutyric acid, a ketone body produced from fatty acids. We confirmed the functional connectivity between nutrient utilization and inflammatory responses and demonstrated enhanced lipid utilization in the hypothalamus providing insights into hypothalamic control of sickness responses. Collectively, these findings could help develop new therapeutic strategies to treat patients with severe sickness symptoms associated with infectious and chronic human diseases.
炎症反应导致的疾病症状出现在多种感染性和慢性疾病中。越来越多的证据表明，改变的营养物质可用性和代谢与炎症过程密切相关。然而，代谢变化与疾病反应发展之间的关系尚未得到充分探索。因此，我们旨在通过给予脂多糖（LPS）的全身性给药的小鼠模型来评估代谢表型，本研究中使用这种方法可诱导出疾病症状。LPS 注射增加了脂质利用和脂肪酸的循环水平。它还增加了β-羟丁酸的水平，β-羟丁酸是由脂肪酸产生的酮体。我们证实了营养物质利用与炎症反应之间的功能连接，并证明了在提供对疾病反应的下丘脑控制见解的下丘脑增强了脂质利用。总的来说，这些发现可能有助于开发新的治疗策略，以治疗与感染和慢性人类疾病相关的严重疾病症状的患者。
