Laboratory for Neurodiversity, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
Laboratory for Neurodiversity, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
Curr Opin Neurobiol. 2021 Aug;69:149-158. doi: 10.1016/j.conb.2021.03.013. Epub 2021 Apr 23.
Dendrite and axon arbors form scaffolds that connect a neuron to its partners; they are patterned to support the specific connectivity and computational requirements of each neuron subtype. Transcription factor networks control the specification of neuron subtypes, and the consequent diversification of their stereotyped arbor patterns during differentiation. We outline how the differentiation trajectories of stereotyped arbors are shaped by hierarchical deployment of precursor cell and postmitotic transcription factors. These transcription factors exert modular control over the dendrite and axon features of a single neuron, create spatial and functional compartmentalization of an arbor, instruct implementation of developmental patterning rules, and exert operational control over the cell biological processes that construct an arbor.
树突和轴突树突形成支架，将神经元与其伙伴连接起来；它们的模式化设计支持每个神经元亚型的特定连接和计算要求。转录因子网络控制神经元亚型的特化，随后在分化过程中其刻板的树突模式多样化。我们概述了刻板树突的分化轨迹如何通过前体细胞和有丝分裂后转录因子的分层部署来塑造。这些转录因子对单个神经元的树突和轴突特征进行模块化控制，创建树突的空间和功能分区，指导发育模式规则的实施，并对构建树突的细胞生物学过程进行操作控制。
