School of Resources and Environment, University of Electronic Science and Technology of China, P.O. Box 611731, Xiyuan Ave, Chengdu, PR China; Department of Chemical Engineering and Energy, Quchan University of Technology, Quchan, 9477177870, Iran; Department of Chemical Sciences, University of Johannesburg, Doornfontein Campus, 2028 Johannesburg, P.O. Box 17011, South Africa.
College of Materials Science and Engineering, Nanjing Forestry University, 159 Longpan Road, Nanjing 210037, China; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China.
Biosens Bioelectron. 2021 Jul 15;184:113252. doi: 10.1016/j.bios.2021.113252. Epub 2021 Apr 17.
Potentiometric-based biosensors have the potential to advance the detection of several biological compounds and help in early diagnosis of various diseases. They belong to the portable analytical class of biosensors for monitoring biomarkers in the human body. They contain ion-sensitive membranes sensors can be used to determine potassium, sodium, and chloride ions activity while being used as a biomarker to gauge human health. The potentiometric based ion-sensitive membrane systems can be coupled with various techniques to create a sensitive tool for the fast and early detection of cancer biomarkers and other critical biological compounds. This paper discusses the application of potentiometric-based biosensors and classifies them into four major categories: photoelectrochemical potentiometric biomarkers, potentiometric biosensors amplified with molecular imprinted polymer systems, wearable potentiometric biomarkers and light-addressable potentiometric biosensors. This review demonstrated the development of several innovative biosensor-based techniques that could potentially provide reliable tools to test biomarkers. Some challenges however remain, but these can be removed by coupling techniques to maximize the testing sensitivity.
基于电位的生物传感器具有检测多种生物化合物的潜力，并有助于早期诊断各种疾病。它们属于便携式分析类生物传感器，用于监测人体中的生物标志物。它们包含离子敏感膜传感器，可用于确定钾、钠和氯离子的活性，同时用作生物标志物来衡量人体健康。基于电位的离子敏感膜系统可以与各种技术结合使用，以创建用于快速和早期检测癌症生物标志物和其他关键生物化合物的敏感工具。本文讨论了基于电位的生物传感器的应用，并将其分为四大类：光电化学电位生物标志物、用分子印迹聚合物系统放大的电位生物传感器、可穿戴电位生物标志物和光寻址电位生物传感器。本综述展示了几种创新的基于生物传感器的技术的发展，这些技术有可能提供可靠的工具来测试生物标志物。然而，仍然存在一些挑战，但通过结合技术来最大限度地提高测试灵敏度，可以消除这些挑战。
