Yim H S, Kibbey C E, Ma S C, Kliza D M, Liu D, Park S B, Espadas Torre C, Meyerhoff M E
Department of Chemistry, University of Michigan, Ann Arbor 48109.
Biosens Bioelectron. 1993;8(1):1-38. doi: 10.1016/0956-5663(93)80041-m.
Recent progress in the design of new polymer membrane-based potentiometric ion-, gas- and bio-selective electrodes in chemistry laboratories at the University of Michigan (Ann Arbor) is reviewed. Emphasis is placed on describing the performance of devices for measuring anions (e.g., salicylate, thiocyanate, chloride and heparin) and gases (e.g., ammonia, carbon dioxide and oxygen) in biological samples, both in vitro and in vivo. Beyond direct measurement of key ions and gases in complex matrices, some of the new membrane electrode systems reported can serve as base transducers for the development of biosensors containing integrated biological reagents, including enzymes and antibodies. New approaches for mass fabricating solid-state ion and biosensor devices as well as future directions for research in the entire field of polymer membrane sensors are also described.
本文综述了密歇根大学（安娜堡分校）化学实验室在新型聚合物膜电位型离子、气体和生物选择性电极设计方面的最新进展。重点描述了用于测量生物样品中阴离子（如水杨酸盐、硫氰酸盐、氯化物和肝素）和气体（如氨、二氧化碳和氧气）的装置在体外和体内的性能。除了直接测量复杂基质中的关键离子和气体外，一些报道的新型膜电极系统还可作为基础换能器，用于开发包含酶和抗体等集成生物试剂的生物传感器。本文还介绍了固态离子和生物传感器器件的大规模制造新方法以及聚合物膜传感器整个领域的未来研究方向。
