Genchi C, Falagiani P, Riva G, Tinelli M, Brunello F, Boero M, Almaviva M
University of Milan.
Ann Allergy. 1988 Jul;61(1):43-6.
The relationship between IgE and IgG antibodies against the metabolic exoantigen of Toxocara canis (TEX antigen) in sera of selected patients with the ocular and visceral form of the disease have been investigated. The specificity and sensitivity of the TEX antigen employed in immunoenzymatic and radioimmunologic assays have been verified. Six hundred and forty-one sera from healthy donors were tested as controls. Our data emphasize the importance of IgE antibodies to ocular larva migrans syndrome and suggest that they play a significant role as a marker of infection. In the visceral form, IgG antibodies seem to mask the presence of IgE by a competitive mechanism toward the same epitopes of the parasite. In fact, IgE antibody titers increase after depletion of IgG from serum.
已对患有眼部和内脏型疾病的特定患者血清中针对犬弓首蛔虫代谢外抗原（TEX抗原）的IgE和IgG抗体之间的关系进行了研究。已验证了免疫酶法和放射免疫法中使用的TEX抗原的特异性和敏感性。对641份来自健康供体的血清进行了检测作为对照。我们的数据强调了IgE抗体对眼部幼虫移行症综合征的重要性，并表明它们作为感染标志物发挥着重要作用。在内脏型中，IgG抗体似乎通过对寄生虫相同表位的竞争机制掩盖了IgE的存在。事实上，血清中IgG耗尽后IgE抗体滴度会增加。
