Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
Department of Dermatology, Jichi Medical University, Shimotsuke, Japan.
J Dermatol. 2021 Jun;48(6):902-906. doi: 10.1111/1346-8138.15924. Epub 2021 Apr 25.
To determine the characteristics of the early phase of psoriatic arthritis (PsA), we conducted a subanalysis of a retrospective survey of Japanese patients. In this study, we enrolled patients with early onset within either 2 years or 1 year from onset among the 1282 patients with PsA that had previously been reported. Among the total reported PsA patients, 304 (23.7%) were diagnosed with less than 2 years of onset of joint manifestation. The male : female ratio was 1.9:1, mean age at onset of cutaneous psoriasis 40.2 years, and that of joint manifestation 50.3 years. Age of less than 20 years at cutaneous psoriasis onset was observed in 22 cases, while that at joint manifestation was observed in two cases. Plaque-type psoriasis accounted for 90.1%, followed by psoriasis erythroderma (3.9%), pustular psoriasis (3.9%), and nail psoriasis (1.3%). Polyarthritis was the most common joint manifestation (32.9%), followed by distal interphalangeal (DIP) type (29.6%), oligoarthritis type (27.3%), and ankylosing spondylitis type (4.9%). Enthesitis was observed in 27.3% and dactylitis in 61.8%. Biologics were used in 168 cases (55.3%). By contrast, 199 patients (15.5%) were diagnosed within 1 year of onset of joint manifestation, among whom polyarthritis was the most common (30.7%). Biologics were used in 50.8%. In conclusion, the present study showed that the frequency of early PsA within 2 years of onset accounted for 23.7%, and those within 1 year of onset was 15.5% among the Japanese patients with PsA. Polyarthritis was the most common in early PsA patients.
为了确定银屑病关节炎（PsA）早期阶段的特征，我们对日本患者的回顾性调查进行了子分析。在这项研究中，我们招募了在之前报告的 1282 例 PsA 患者中，从发病到发病 2 年内或 1 年内发病的早期患者。在报告的所有 PsA 患者中，有 304 例（23.7%）的关节表现发病不到 2 年。男女比例为 1.9:1，皮肤银屑病发病时的平均年龄为 40.2 岁，关节表现发病时的平均年龄为 50.3 岁。发病时年龄小于 20 岁的有 22 例，发病时年龄小于 20 岁的有 2 例。斑块型银屑病占 90.1%，其次是银屑病红皮病（3.9%）、脓疱型银屑病（3.9%）和甲银屑病（1.3%）。多关节炎是最常见的关节表现（32.9%），其次是远端指间关节（DIP）型（29.6%）、少关节炎型（27.3%）和强直性脊柱炎型（4.9%）。附着点炎见于 27.3%，指骨炎见于 61.8%。168 例（55.3%）使用生物制剂。相比之下，199 例（15.5%）在发病 1 年内被诊断为关节表现，其中多关节炎最常见（30.7%）。50.8%的患者使用了生物制剂。总之，本研究表明，日本 PsA 患者中，2 年内发病的早期 PsA 频率为 23.7%，1 年内发病的频率为 15.5%。多关节炎是早期 PsA 患者中最常见的类型。
