Martins Thiago Goncalves Dos Santos, Miranda Sipahi Aytan, Dos Santos Fabiana Maria, Schor Paulo, Anschütz Andreas, Mendes Luís Guilherme Arneiro, Silva Rufino
Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Clinical and Experimental Gastroenterology Laboratory-LIM07, HCFMUSP Clinical Hospital, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Eur J Ophthalmol. 2021 Apr 25:11206721211012849. doi: 10.1177/11206721211012849.
To analyze the prevalence of ophthalmic manifestations in patients with celiac disease, Crohn's disease and ulcerative colitis in Munich/Germany.
A total of 272,873 patients of Ludwig Maximilians Universitat Ophthalmological Hospital with eye disease were evaluated between 2003 and 2019. The International Classification of Diseases, 10th revision (ICD-10) of celiac disease Crohn's disease, ulcerative colitis, and all medical records which had the diagnosis of these diseases were analyzed.
A total of 272,873 patients were analyzed, with a mean age of 53 years, with approximately 48% female patients, and 51% male patients. We selected 72 patients with celiac disease (68% women and 32% men), with a minimum age of 8 years, maximum of 103 years, and an average of 52 years. The most common diagnoses were dry eye (32%) and cataract (12%). The mean intraocular pressure of patients with celiac disease was 15 mmHg. During the same study period, 103 patients with Crohn's disease were analyzed, with an average intraocular pressure of 14 mmHg.The minimum age of the patients was 12 years and a maximum of 93 years with an average age of 55 years, with 57% of females and 43% of males. The most common diagnoses were cataract (22%) and dry eye (19%). During the same study period, 99 patients with ulcerative colitis were analyzed, with an average intraocular pressure of 14 mmHg.The minimum age of the patients was 6 years and a maximum of 96 years, with an average age of 61 years, with 36% of females and 64% of males. The most common diagnoses were cataract (29.2%) and dry eye (12%).
The main ophthalmological manifestations of patients requiring eye follow-up were dry eye and cataract for all the diseases analyzed, which can be considered as coincident complications. None of the three diseases had increased intraocular pressure. Thus, celiac disease presented a profile of ophthalmological manifestation similar to the other intestinal inflammatory diseases studied.
分析德国慕尼黑乳糜泻、克罗恩病和溃疡性结肠炎患者眼部表现的患病率。
对2003年至2019年间路德维希·马克西米利安大学眼科医院的272,873例眼病患者进行评估。分析了国际疾病分类第10版（ICD - 10）中乳糜泻、克罗恩病、溃疡性结肠炎以及所有诊断有这些疾病的病历。
共分析了272,873例患者，平均年龄53岁，女性患者约占48%，男性患者占51%。我们选取了72例乳糜泻患者（女性占68%，男性占32%），年龄最小8岁，最大103岁，平均52岁。最常见的诊断是干眼症（32%）和白内障（12%）。乳糜泻患者的平均眼压为15 mmHg。在同一研究期间，分析了103例克罗恩病患者，平均眼压为14 mmHg。患者年龄最小12岁，最大93岁，平均年龄55岁，女性占57%，男性占43%。最常见诊断是白内障（22%）和干眼症（19%）。在同一研究期间，分析了99例溃疡性结肠炎患者，平均眼压为14 mmHg。患者年龄最小6岁，最大96岁，平均年龄61岁，女性占36%，男性占64%。最常见诊断是白内障（29.2%）和干眼症（12%）。
对于所有分析的疾病，需要眼部随访的患者主要眼部表现是干眼症和白内障，可视为并发并发症。这三种疾病均未出现眼压升高。因此，乳糜泻呈现出与所研究的其他肠道炎症性疾病相似的眼部表现特征。
