The Medicine Department, The Royal Hospital, Muscat, Oman.
The Medicine Department, MOHAP, Dubai, UAE.
Ren Fail. 2021 Dec;43(1):664-675. doi: 10.1080/0886022X.2021.1915798.
Worldwide, there is a global progressive rise of chronic kidney disease. In parallel, children born after intra-uterine growth retardation are surviving to adult-life and beyond. This study describes the association of birthweight with and estimated glomerular filtration rate (eGFR).
Australian Diabetes, Obesity and Lifestyle (AusDiab) study participants were asked to complete a birthweight questionnaire. The associations between birthweight and eGFR were determined.
A total of 4502 reported information related to their birthweight, with the other responders did not provide a value. The birthweight of the participants ranged from 0.4 to 7.0 kg with a mean-(SD) of 3.37 (0.7) kg. The mean (95%CI) birthweight was lower for females, 3.28 (0.6) kg, when compared to males, 3.5 (0.7) kg. Eight percent had a birthweight less than 2.5 kg. The eGFR was strongly and positively associated with birthweight, with people in the lowest sex-specific birthweight-quintiles having the lowest mean eGFR. This relationship persisted with adjustment for confounding factors. The OR(CI) for eGFR <10th-percentile (<61.4 ml/min for females and <73.4 for males) for people in the lowest vs. the higher birthweight-quintile was 2.19 (95%CI 1.14-4.2) for females and 2.37 (1.1-5.3) for males, after adjustment for other factors.
Birthweight had a positive relationship with eGFR. Possible explanations include an association of birthweight with nephron-endowment. From a global health perspective but more in developing countries and in populations in epidemiologic transition, where substantially lower birthweights coexist with recently improved infant and adult survivals, the overall impact of this phenomenon on the population health profile could be more substantial.
在全球范围内，慢性肾脏病的发病率呈全球性上升趋势。与此同时，宫内生长迟缓后出生的儿童能够存活到成年期及以后。本研究描述了出生体重与估算肾小球滤过率（eGFR）的关系。
澳大利亚糖尿病、肥胖和生活方式（AusDiab）研究的参与者被要求完成一份出生体重问卷。确定了出生体重与 eGFR 之间的关系。
共有 4502 人报告了与他们的出生体重有关的信息，其他没有提供数值的响应者。参与者的出生体重范围为 0.4 至 7.0kg，平均值（SD）为 3.37（0.7）kg。女性的平均（95%CI）出生体重较低，为 3.28（0.6）kg，而男性为 3.5（0.7）kg。8%的人出生体重低于 2.5kg。eGFR 与出生体重呈强烈正相关，出生体重最低的性别特定五分位数人群的平均 eGFR 最低。这种关系在调整混杂因素后仍然存在。出生体重最低五分位数人群（女性<61.4ml/min，男性<73.4ml/min）与出生体重较高五分位数人群相比，eGFR<10%的 OR（CI）为女性 2.19（95%CI 1.14-4.2），男性 2.37（1.1-5.3）。
出生体重与 eGFR 呈正相关。可能的解释包括出生体重与肾单位储备有关。从全球健康的角度来看，但在发展中国家和处于流行病学转变中的人群中，出生体重明显降低与最近婴儿和成人存活率提高并存，这种现象对人群健康状况的总体影响可能更为显著。
