Escuela de Ingeniería de Bilbao, Departamento de Ingeniería Minera, Metalúrgica y Ciencia de Materiales, Universidad del País Vasco (UPV/EHU), Portugalete, Spain.
BCMaterials, Basque Centre for Materials, Applications and Nanostructures, UPV/EHU Science Park, Leioa, Spain.
J Biomater Sci Polym Ed. 2021 Aug;32(11):1406-1419. doi: 10.1080/09205063.2021.1922023. Epub 2021 Jun 1.
Poly(L-lactide)/reduced graphene oxide (PLLA/rGO) scaffolds were studied in the present work. The scaffolds were fabricated by TIPS (thermally induced phase separation). Nonisothermal crystallization study for PLLA/rGO was investigated and revealed the nucleating effect of rGO. rGO effect on cytotoxicity, thermal properties, and hydrolysis resistance of PLLA and PLLA/rGO scaffolds were analysed. degradation in phosphate-buffered solution at 37 °C is analyzed over twelve weeks. A high crystalline behaviour reduces the speed of hydrolysis and therefore implies less variation in pH, mass loss and water up take. The rGO does not seem to accelerate the degradation process. Finally, rGO contents in PLLA up to 1 wt% dos not lead to cytotoxic effect, the scaffolds supporting cell adhesion and proliferation.
本工作研究了聚（L-乳酸）/还原氧化石墨烯（PLLA/rGO）支架。支架采用热致相分离（TIPS）法制备。对 PLLA/rGO 的非等温结晶研究表明了 rGO 的成核作用。分析了 rGO 对 PLLA 和 PLLA/rGO 支架的细胞毒性、热性能和耐水解性的影响。在 37°C 的磷酸盐缓冲溶液中进行了为期十二周的降解分析。高结晶行为降低了水解速度，因此 pH 值、质量损失和吸水率的变化较小。rGO 似乎并没有加速降解过程。最后，rGO 在 PLLA 中的含量高达 1wt% 不会导致细胞毒性，支架支持细胞黏附和增殖。
