Department of Immunology and Pathology, Baylor College of Medicine, and Texas Children's Microbiome Center, Texas Children's Hospital, Houston, TX, 77030, USA.
Israel Institute for Biological Research, Ness Ziona, Israel, 74100, Israel.
Trends Parasitol. 2021 Aug;37(8):747-761. doi: 10.1016/j.pt.2021.03.010. Epub 2021 Apr 22.
Nearly half a million people die annually due to mosquito-borne diseases. Despite aggressive mosquito population-control efforts, current strategies are limited in their ability to control these vectors. A better understanding of mosquito metabolism through modern approaches can contribute to the discovery of novel metabolic targets and/or regulators and lead to the development of better mosquito-control strategies. Currently, cutting-edge technologies such as gas or liquid chromatography-mass spectrometry-based metabolomics are considered 'mature technologies' in many life-science disciplines but are still an emerging area of research in medical entomology. This review primarily discusses recent developments and progress in the application of mass spectrometry-based metabolomics to answer multiple biological questions related to mosquito metabolism.
每年有近 50 万人死于蚊虫传播的疾病。尽管采取了积极的蚊虫种群控制措施，但目前的策略在控制这些媒介方面的能力有限。通过现代方法更好地了解蚊子的新陈代谢，可以有助于发现新的代谢靶标和/或调节剂，并开发出更好的蚊子控制策略。目前，基于气相或液相色谱-质谱的代谢组学等尖端技术在许多生命科学学科中被认为是“成熟技术”，但在医学昆虫学领域仍是一个新兴的研究领域。本文主要讨论了基于质谱的代谢组学在回答与蚊子代谢相关的多个生物学问题中的应用的最新进展和进展。
