Department of Gastroenterology, Toyama University Hospital, Japan.
Department of Community Medical Support, Toyama University Hospital, Japan.
Intern Med. 2021 Oct 15;60(20):3239-3243. doi: 10.2169/internalmedicine.7132-21. Epub 2021 Apr 26.
Accurate genotyping is important to improve the treatment of hepatitis C virus (HCV) infection. We herein report a 44-year-old Japanese man with hemophilia A and coinfection of HCV and human immunodeficiency virus (HIV) who was diagnosed with HCV genotype 4 by direct sequencing. Two genotyping tests based on the nested polymerase chain reaction method that we used misdiagnosed his genotype as 2b and 1b. Although several HCV genotyping tests are available in Japan, it is important to recognize that some cannot detect genotype 4. Care should be taken when genotyping HCV patients who have received non-heated coagulation factor preparations or were infected abroad.
准确的基因分型对于改善丙型肝炎病毒（HCV）感染的治疗至关重要。我们在此报告一例 44 岁的日本男性，患有血友病 A 和 HCV 与人类免疫缺陷病毒（HIV）合并感染，通过直接测序诊断为 HCV 基因型 4。我们使用的基于巢式聚合酶链反应方法的两种基因分型检测错误地将其基因型诊断为 2b 和 1b。尽管日本有几种 HCV 基因分型检测方法，但重要的是要认识到有些方法可能无法检测到基因型 4。对于那些接受过未加热的凝血因子制剂或在国外感染的 HCV 患者进行基因分型时应谨慎。
