Isiordia-Espinoza Mario Alberto, Sánchez-Prieto Martín, Tobías-Azúa Francisco, Reyes-García Juan Gerardo, Granados-Soto Vinicio
Department of Clinical Research, Unidad Académica de Odontología, Universidad Autónoma de Nayarit, Tepic, Mexico.
Br J Oral Maxillofac Surg. 2012 Oct;50(7):673-7. doi: 10.1016/j.bjoms.2011.12.003. Epub 2012 Jan 4.
The aim of this pilot study was to evaluate pre-emptive analgesia using the combination tramadol plus meloxicam compared with each individual drug alone for the reduction of pain after extraction of third molars. Fifty-one patients were randomised into three groups (n=17 in each), using a series of random numbers: the first group was given tramadol 25mg and meloxicam 7.5mg; the second tramadol 50mg, and the third meloxicam 15 mg, all intramuscularly. Treatments were prepared in identical syringes by an independent investigator and were given immediately. The teeth were removed 50 min after the analgesics had been given. Intensity of pain, consumption of analgesics, and adverse effects were evaluated. The intensity of pain was evaluated using a visual analogue scale (VAS) and the area under the curve of the VAS showed significant differences amongst the groups. In conclusion, the study showed that the combination of tramadol 25mg and meloxicam 7.5mg had an analgesic effect similar to that of meloxicam 15 mg, but both were better than tramadol 50mg for relief of pain after the extraction of mandibular third molars.
这项初步研究的目的是评估曲马多联合美洛昔康进行超前镇痛与单独使用每种药物相比，对拔除第三磨牙后疼痛减轻的效果。51名患者通过一系列随机数字被随机分为三组（每组n = 17）：第一组给予曲马多25mg和美洛昔康7.5mg；第二组给予曲马多50mg，第三组给予美洛昔康15mg，均为肌肉注射。治疗药物由一名独立研究人员用相同的注射器配制，并立即给药。在给予镇痛药50分钟后拔除牙齿。评估疼痛强度、镇痛药消耗量和不良反应。使用视觉模拟量表（VAS）评估疼痛强度，VAS曲线下面积在各组之间显示出显著差异。总之，研究表明曲马多25mg和美洛昔康7.5mg联合使用的镇痛效果与美洛昔康15mg相似，但两者在缓解下颌第三磨牙拔除术后疼痛方面均优于曲马多50mg。
