副肿瘤性眼阵挛中的一种抗神经元自身抗体。
An antineuronal autoantibody in paraneoplastic opsoclonus.
作者信息
Budde-Steffen C, Anderson N E, Rosenblum M K, Graus F, Ford D, Synek B J, Wray S H, Posner J B
机构信息
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
出版信息
Ann Neurol. 1988 May;23(5):528-31. doi: 10.1002/ana.410230518.
Sera from 7 patients with paraneoplastic opsoclonus were examined for antineuronal autoantibodies. An antibody against neuronal nuclei was found in serum from a patient with breast cancer, opsoclonus, and ataxia. This antibody recognized 53- to 61-kDa and 79- to 84-kDa antigens in immunoblots of neurons. Antineuronal antibodies were not found in other patients with paraneoplastic opsoclonus.
对7例副肿瘤性眼阵挛患者的血清进行抗神经元自身抗体检测。在一名患有乳腺癌、眼阵挛和共济失调的患者血清中发现了一种抗神经元细胞核抗体。该抗体在神经元免疫印迹中识别53至61 kDa和79至84 kDa的抗原。在其他副肿瘤性眼阵挛患者中未发现抗神经元抗体。
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