Deckers C, Deckers-Passau L, Dubucq-mace F
Lab Anim Sci. 1977 Oct;27(5 Pt 2):733-7.
An immunoglobulin secreting tumor appeared spontaneouldy in the LOU/Dec rat strain in an incidence of about 3--5% at age 8-20 months. Attempts to increase the incidence using such things as genetic selection, carcinogens, immunosuppressants, adjuvants, cell-free fumor material, and antigenic stimulation were unsuccessful. The tumor was found to be easily transplanted. It secreted monocolonal immunoglobulins related to most of the normal rat immunoglobulins: IgG, IgA, IgM, IgE, and some light chains. Some tumor lines were found to be sensitive to chemotherapy. Tumor-bearing rats, cured by chemotherapy, were found to be resistant to subsequent challenge graft of the tumor. The resistant state could be transferred from one animal to another by parabiosis or peritoneal exudate, but not by way of serum. It was concluded that the tumor-bearing LOU/Dec rat is an excellent model for studies of immunoglobulin secretion, and the cured, resistant rat is an excellent model for studies of cell mediated immunity.
在LOU/Dec大鼠品系中，一种分泌免疫球蛋白的肿瘤自发出现，8至20月龄大鼠的发病率约为3%-5%。尝试通过基因选择、致癌物、免疫抑制剂、佐剂、无细胞肿瘤物质和抗原刺激等方法来提高发病率均未成功。发现该肿瘤易于移植。它分泌与大多数正常大鼠免疫球蛋白相关的单克隆免疫球蛋白：IgG、IgA、IgM、IgE和一些轻链。发现一些肿瘤细胞系对化疗敏感。经化疗治愈的荷瘤大鼠对随后的肿瘤攻击移植具有抗性。这种抗性状态可通过联体共生或腹腔渗出液从一只动物转移到另一只动物，但不能通过血清转移。得出的结论是，荷瘤LOU/Dec大鼠是研究免疫球蛋白分泌的极佳模型，而治愈的抗性大鼠是研究细胞介导免疫的极佳模型。
