活化巨噬细胞的体内和体外功能测试之间的相关性
Correlation between in vivo and in vitro functional tests for activated macrophages.
作者信息
Rhodes J M, Bennedsen J, Larsen S O, Riisgaard S, Spärck J V
出版信息
Infect Immun. 1979 Jan;23(1):34-40. doi: 10.1128/iai.23.1.34-40.1979.
Abstract
Mice undergoing graft-versus-host reaction, skin grafting, and inoculation with tumor cells were tested for nonspecific resistance by intravenous challenge with Listeria monocytogenes. Peritoneal exudate macrophages from mice treated in a similar manner were tested in vitro for increased degradation of [1-14C]glucose, ability to degrade antigen/antibody complexes, ability to inhibit intracellular growth of listeria, and staining for beta-galactosidase. There was good correlation between in vivo resistance towards L. monocytogenes and in vitro inhibition of intracellular growth. There was also good correlation between increase in beta-galactosidase and in vivo resistance in mice undergoing a graft-versus-host-reaction.
摘要
对经历移植物抗宿主反应、皮肤移植和接种肿瘤细胞的小鼠，通过静脉注射单核细胞增生李斯特菌进行非特异性抗性测试。对以类似方式处理的小鼠的腹腔渗出巨噬细胞进行体外测试，检测其对[1-¹⁴C]葡萄糖降解增加、降解抗原/抗体复合物的能力、抑制李斯特菌细胞内生长的能力以及β-半乳糖苷酶染色情况。体内对单核细胞增生李斯特菌的抗性与体外对细胞内生长的抑制之间存在良好相关性。在经历移植物抗宿主反应的小鼠中，β-半乳糖苷酶增加与体内抗性之间也存在良好相关性。
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