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对正常、受刺激及免疫激活的小鼠巨噬细胞的体外研究。II. 放射性抗原/抗体复合物的降解

In vitro studies on normal, stimulated and immunologically activated mouse macrophages. II. Degradation of radioactive antigen/antibody complexes.

作者信息

Rhodes J M, Nielsen G, Larsen S O, Bennedsen J, Riisgaard S

出版信息

Acta Pathol Microbiol Scand C. 1977 Aug;85C(4):239-45. doi: 10.1111/j.1699-0463.1977.tb03637.x.

DOI:10.1111/j.1699-0463.1977.tb03637.x
PMID:331866
Abstract

Radioactive antigen/antibody complexes are degraded to a greater extent by PE macrophages from C3H, CBA and C57Bl mice injected intraperitoneally with proteose-peptone (stimulated macrophages) and T.A.B. vaccine than by PE macrophages from normal mice and mice immunized with BCG (activated macrophages). On the other hand, spleen macrophages from mice immunized with BCG had a greater digestive capacity than macrophages from mice injected with proteose-peptone or T.A.B. vaccine or from normal mice. Thus, activated macrophages are capable of degrading antigen/antibody complexes, provided that the cells are harvested from one of the foci of BCG infection.

摘要

放射性抗原/抗体复合物在更大程度上被来自经腹腔注射蛋白胨(刺激的巨噬细胞)和伤寒、副伤寒甲和乙三联疫苗的C3H、CBA和C57Bl小鼠的腹腔渗出巨噬细胞(PE巨噬细胞)降解,而不是被来自正常小鼠和用卡介苗免疫的小鼠(活化的巨噬细胞)的PE巨噬细胞降解。另一方面,用卡介苗免疫的小鼠的脾巨噬细胞比注射蛋白胨或伤寒、副伤寒甲和乙三联疫苗的小鼠或正常小鼠的巨噬细胞具有更强的消化能力。因此,只要从卡介苗感染灶之一收获细胞,活化的巨噬细胞就能够降解抗原/抗体复合物。

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Cancer Immunol Immunother. 1982;13(2):93-7. doi: 10.1007/BF00205307.
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Correlation between in vivo and in vitro functional tests for activated macrophages.活化巨噬细胞的体内和体外功能测试之间的相关性
Infect Immun. 1979 Jan;23(1):34-40. doi: 10.1128/iai.23.1.34-40.1979.