Weyer-Jamora Christina, Brie Melissa S, Luks Tracy L, Smith Ellen M, Braunstein Steve E, Villanueva-Meyer Javier E, Bracci Paige M, Chang Susan, Hervey-Jumper Shawn L, Taylor Jennie W
Department of Neurological Surgery, University of California San Francisco.
Department of Psychiatry and Behavioral Sciences, Zuckerberg San Francisco General Hospital, California.
Neurooncol Pract. 2020 Nov 4;8(2):117-128. doi: 10.1093/nop/npaa072. eCollection 2021 Apr.
Outcomes for patients with lower-grade gliomas (LrGGs) continue to improve with advances in molecular characterization and treatment. However, cognitive sequela from the tumor and its treatment leave a significant impact on health-related quality of life for these patients. Several factors affect each patient's cognition, such as tumor location, treatment, medication, and comorbidities. However, impairments of processing speed, attention, concentration, working memory, and executive function are common across LrGG patients. Cognitive rehabilitation strategies, well established in traumatic brain injury and stroke populations, are based on neural plasticity and functional reorganization. Adapting these strategies for implementation in patients with brain tumors is an active area of research. This article provides an overview of cognitive domains commonly impaired in LrGG patients and evidence for the use of cognitive rehabilitation strategies to address these impairments with the goal of improving health-related quality of life in this patient population.
随着分子特征分析和治疗方法的进步，低级别胶质瘤（LrGGs）患者的预后持续改善。然而，肿瘤及其治疗引起的认知后遗症对这些患者的健康相关生活质量产生了重大影响。有几个因素会影响每个患者的认知，如肿瘤位置、治疗、药物和合并症。然而，处理速度、注意力、专注力、工作记忆和执行功能的损害在LrGG患者中很常见。认知康复策略在创伤性脑损伤和中风人群中已得到充分确立，其基于神经可塑性和功能重组。将这些策略应用于脑肿瘤患者是一个活跃的研究领域。本文概述了LrGG患者中常见的认知领域受损情况，以及使用认知康复策略来解决这些损害的证据，目的是改善该患者群体的健康相关生活质量。
