Xiao Yinglian, Tan Jing, Cheng Guo, Deng Yanhong
Department of Neurosurgery, Chongqing University Cancer Hospital, Chongqing, China.
PLoS One. 2025 Feb 25;20(2):e0319220. doi: 10.1371/journal.pone.0319220. eCollection 2025.
Social Participation (SP) is known to benefit cognitive function. However, whether this positive relationship holds across the people with glioma has not been studied. The present study aimed to investigate the current status of SP and cognitive function of patients early after surgery with glioma, and therefore, explore the associations between cognitive function and SP.
This study included 179 postoperative patients with gliomas within 6 months of surgery. Cognitive functioning was measured by the Montreal Cognitive Assessment (MoCA) including orientation, attention, learning and memory, executive functioning and verbal fluency. Social participation was obtained also by questionnaire survey with the Impact on Participation and Autonomy Questionnaire (IPA). The Pearson correlation analysis was used to explore the relation between cognitive functioning and social participation, and the efficacy of social participation in predicting cognitive functioning was evaluated using the receiver operating characteristic (ROC).
The prevalence of cognitive impairment in early postoperative glioma patients was 77.65%. The mean level of social participation was 37.96 ± 26.85 points, with poorer scores in the autonomy participation of family role and outdoor engagement dimensions. Patients' cognitive functioning was positively correlated with social participation (r = -0.64, P < 0.001). And The areas under the ROC curve for social participation predicting cognitive function were 0.884.
Early post-operative cognitive impairment was more common in glioma patients, which was positively correlated with social participation. Social rehabilitation programs for glioma patients should be actively constructed to promote the social participation of patients early after surgery in order to protect their cognitive function.
已知社会参与（SP）有益于认知功能。然而，这种正向关系在胶质瘤患者中是否成立尚未得到研究。本研究旨在调查胶质瘤手术后早期患者的社会参与和认知功能现状，进而探讨认知功能与社会参与之间的关联。
本研究纳入了179例术后6个月内的胶质瘤患者。认知功能通过蒙特利尔认知评估（MoCA）进行测量，包括定向、注意力、学习与记忆、执行功能和语言流畅性。社会参与情况也通过使用参与和自主影响问卷（IPA）进行问卷调查获得。采用Pearson相关分析来探讨认知功能与社会参与之间的关系，并使用受试者工作特征曲线（ROC）评估社会参与对认知功能的预测效能。
胶质瘤术后早期患者认知障碍的患病率为77.65%。社会参与的平均水平为37.96±26.85分，在家庭角色自主参与和户外参与维度得分较低。患者的认知功能与社会参与呈正相关（r = -0.64，P < 0.001）。社会参与预测认知功能的ROC曲线下面积为0.884。
胶质瘤患者术后早期认知障碍较为常见，且与社会参与呈正相关。应积极构建胶质瘤患者的社会康复项目，以促进患者术后早期的社会参与，从而保护其认知功能。
