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他汀类药物诱发的自身免疫性心肌炎、肌炎和转氨酶升高三联征。

Statin-Induced Triad of Autoimmune Myocarditis, Myositis, and Transaminitis.

作者信息

Ajmal Muhammad, Singh Amitoj, Kubba Saad, Hershman Michelle, Acharya Tushar

机构信息

Division of Cardiology, Department of Internal Medicine, USA.

Department of Medical Imaging, University of Arizona College of Medicine, Tucson, USA.

出版信息

Case Rep Cardiol. 2021 Apr 8;2021:6660362. doi: 10.1155/2021/6660362. eCollection 2021.

DOI:10.1155/2021/6660362
PMID:33898067
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8052178/
Abstract

Despite well-established cardiovascular benefits, statins have been associated with myopathic side effects ranging from myalgias to rhabdomyolysis and autoimmune necrotizing myositis. Statins have not been previously shown to cause myocarditis. Our case highlights this rare entity.

摘要

尽管他汀类药物具有公认的心血管益处，但已发现其存在从肌痛到横纹肌溶解以及自身免疫性坏死性肌炎等肌病副作用。此前尚未发现他汀类药物会引发心肌炎。我们的病例突出了这种罕见情况。

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Statin-Induced Triad of Autoimmune Myocarditis, Myositis, and Transaminitis.他汀类药物诱发的自身免疫性心肌炎、肌炎和转氨酶升高三联征。
Case Rep Cardiol. 2021 Apr 8;2021:6660362. doi: 10.1155/2021/6660362. eCollection 2021.
2
Necrotizing Autoimmune myopathy: A case report on statin induced rhabdomyolysis requiring immunosuppressive therapy.坏死性自身免疫性肌病：一例关于他汀类药物诱导的横纹肌溶解症需免疫抑制治疗的病例报告。
Drug Discov Ther. 2018;12(5):315-317. doi: 10.5582/ddt.2018.01049.
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Statin-induced myalgia and myositis: an update on pathogenesis and clinical recommendations.他汀类药物引起的肌肉疼痛和肌炎：发病机制和临床建议的更新。
Expert Rev Clin Immunol. 2018 Mar;14(3):215-224. doi: 10.1080/1744666X.2018.1440206. Epub 2018 Feb 23.
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Statin-associated autoimmune myopathy and anti-HMGCR autoantibodies.他汀类药物相关性自身免疫性肌病与抗 HMGCR 自身抗体。
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Does statin therapy initiation increase the risk for myopathy? An observational study of 32,225 diabetic and nondiabetic patients.开始他汀类药物治疗会增加患肌病的风险吗？一项对32225名糖尿病和非糖尿病患者的观察性研究。
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Subacute Cardiomyopathy Due to Statin Treatment: Can It Be True?-Case Report and Literature Review.他汀类药物治疗所致亚急性心肌病：这可能是真的吗？——病例报告及文献综述
Life (Basel). 2025 Apr 9;15(4):630. doi: 10.3390/life15040630.
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Statin-induced immune mediated necrotising myopathy presenting with a markedly elevated cardiac troponin T in the absence of myocardial injury.他汀类药物诱导的免疫介导坏死性肌病，在无心肌损伤的情况下出现心肌肌钙蛋白T显著升高。
Oxf Med Case Reports. 2025 Feb 22;2025(2):omae190. doi: 10.1093/omcr/omae190. eCollection 2025 Feb.
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本文引用的文献

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Statin-induced necrotizing autoimmune myopathy: an extremely rare adverse effect from statin use.他汀类药物诱导的坏死性自身免疫性肌病：他汀类药物使用极为罕见的不良反应。
J Community Hosp Intern Med Perspect. 2019 Dec 14;9(6):503-506. doi: 10.1080/20009666.2019.1702272. eCollection 2019.
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2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.2018 年美国心脏病学会/美国心脏协会/美国心血管血管造影和介入学会/美国预防、物理治疗和康复医师学会/美国糖尿病协会/美国老年学会/美国药学会/美国医师协会/美国生理学会/北美介入放射学会/美国国家脂质协会/美国临床内分泌医师协会胆固醇管理指南：美国心脏病学会/美国心脏协会临床实践指南工作组的报告。
Circulation. 2019 Jun 18;139(25):e1082-e1143. doi: 10.1161/CIR.0000000000000625. Epub 2018 Nov 10.
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他汀类药物的使用与新冠病毒病及其他呼吸道感染的关系：肌肉及其他考量因素
J Clin Med. 2023 Jul 13;12(14):4659. doi: 10.3390/jcm12144659.
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Statin-Induced Myositis with Concomitant Myocarditis.他汀类药物诱发的肌炎伴发心肌炎
Cureus. 2022 Nov 24;14(11):e31871. doi: 10.7759/cureus.31871. eCollection 2022 Nov.
Statin-Associated Autoimmune Myopathy: A Systematic Review of 100 Cases.他汀类药物相关自身免疫性肌病：100例病例的系统评价
J Clin Rheumatol. 2017 Apr;23(3):149-154. doi: 10.1097/RHU.0000000000000497.
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Statin-Associated Autoimmune Myopathy.他汀类药物相关自身免疫性肌病
N Engl J Med. 2016 Feb 18;374(7):664-9. doi: 10.1056/NEJMra1515161.
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Statins as a new therapeutic perspective in myocarditis and postmyocarditis dilated cardiomyopathy: editorial to "Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice" by K. Tajiri et al.
Cardiovasc Drugs Ther. 2013 Oct;27(5):365-9. doi: 10.1007/s10557-013-6475-8.
6
Amelioration of myocarditis by statin through inhibiting cross-talk between antigen presenting cells and lymphocytes in rats.他汀类药物通过抑制大鼠抗原呈递细胞与淋巴细胞之间的相互作用改善心肌炎
J Mol Cell Cardiol. 2008 Jun;44(6):1023-1031. doi: 10.1016/j.yjmcc.2008.03.016. Epub 2008 Apr 1.
7
Statin safety: a systematic review.他汀类药物的安全性：一项系统评价。
Am J Cardiol. 2006 Apr 17;97(8A):52C-60C. doi: 10.1016/j.amjcard.2005.12.010. Epub 2006 Feb 3.