IRD, AP-HM, MEPHI, Aix Marseille University, Marseille, France.
IHU Méditerranée Infection, Marseille, France.
Open Vet J. 2021 Jan-Mar;11(1):165-173. doi: 10.4314/ovj.v11i1.24. Epub 2021 Mar 10.
Rodents are one of the most dangerous reservoirs and carriers of infectious diseases. Gradually, rats have become predominant in cities, sometimes staying in close vicinity to humans, pets, and other animals. Consequently, they tend to increase the transmission risk of pathogens.
Here, we report an original case of bacterial pneumonia in a street rat (). The rat was found dead on a street in the chief town of Marseille (France) after being run over by a car. The necropsy of the corpse revealed generalized granulomatous pneumonia in almost all the pulmonary lobes. Lung lesions and predominantly multiple fibro-inflammatory areas are presumably the witness of an infectious etiology. Bacterial isolation was carried out from lung tissues. Colonies were identified by MALDI-TOF MS and confirmed by 16S rRNA sequencing. The following bacteria were identified: , , , and . Based on the histopathological diagnosis and the avoidance approach, the most likely etiological agent of pneumonia is therefore , a little-known Pasteurellales bacterium that is closely related to
These data emphasize the severity of infection in rodents. Thus, pointing out a potential risk for other animals (dogs, cats, and birds), as well as humans. The health monitoring program for rodents and rabbits pasteurellosis should now include . Therefore, the pathological effect of the species and/or strains needs to be better explored.
啮齿动物是最危险的传染病储存库和携带者之一。逐渐地，老鼠在城市中占据了主导地位，有时它们会靠近人类、宠物和其他动物。因此，它们往往会增加病原体的传播风险。
在这里，我们报告了一例街头老鼠（）细菌性肺炎的原始病例。这只老鼠在法国马赛市（法国）的一条街道上被车撞死。尸体解剖显示，几乎所有的肺叶都有弥漫性肉芽肿性肺炎。肺部病变和主要的多发性纤维炎症区域可能是感染病因的证据。从肺组织中进行了细菌分离。通过 MALDI-TOF MS 鉴定出菌落，并通过 16S rRNA 测序进行了确认。鉴定出以下细菌： 、 、 、 。基于组织病理学诊断和回避方法，肺炎的最可能病因是 ，一种鲜为人知的巴斯德氏菌科细菌，与 密切相关。
这些数据强调了啮齿动物感染的严重性。因此，这表明了对其他动物（狗、猫和鸟）以及人类的潜在风险。现在，应该将鼠兔巴氏杆菌病的啮齿动物和兔健康监测计划包括 。因此，需要更好地探索该物种和/或菌株的病理作用。
