Biello Katie B, Horvitz Casey, Mullin Shelby, Mayer Kenneth H, Scott Hyman, Coleman Kenneth, Dormitzer Julian, Norelli Jenna, Hightow-Weidman Lisa, Sullivan Patrick, Mimiaga Matthew J, Buchbinder Susan, Bojan Kelly, Futterman Donna, Emmanuel Patricia, Liu Albert
Departments of Behavioral & Social Health Sciences and Epidemiology, School of Public Health, Brown University, Providence, RI, USA.
The Fenway Institute, Fenway Health, Boston, MA, USA.
Mhealth. 2021 Apr 20;7:26. doi: 10.21037/mhealth-20-70. eCollection 2021.
Young men who have sex with men (YMSM) are disproportionately impacted by HIV and other sexually transmitted infections (STIs) in the United States (US) and have low rates of HIV/STI testing. Provision of HIV self-testing and STI self-collection can increase testing rates, and access to these kits through mobile applications (apps) could help facilitate YMSM using HIV self-testing and STI self-collection.
Data for this study comes from two pilot randomized controlled trials (RCTs) of mobile apps within the Adolescent Trials Network-LYNX and MyChoices-aimed to increase HIV/STI testing among YMSM (age 15-24) who had not recently tested for HIV and were at high risk for HIV acquisition across five US cities. Both apps include the ability to order a HIV self-test with rapid results and a kit for STI self-collection and mailing of samples for syphilis, gonorrhea and chlamydia to a lab for testing. Using assessments of app users (n=80) at pre-randomization and at 3- and 6-months post-randomization and online interview data from a purposive sample of app users (n=37), we report on experiences and lessons learned with HIV self-testing and STI self-collection kits ordered via the apps.
Participants were on average 20.7 years of age (SD =2.4), and 49% were non-White or multiple race/ethnicity. Sixty-three percent had a prior HIV test. Over half (58%) had a prior STI test, but only 3% had tested within the past 3 months. Nearly two-thirds ordered an HIV self-testing kit; of whom, 75% reported using at least one self-test kit over the study period. STI self-collection kit ordering rates were also high (54%); however, STI self-collection kit return rates were lower (13%), but with a high positivity rate (5.3%). Both HIV self-testing and STI self-collection kits were highly acceptable, and 87% reported that it was extremely/very helpful to be able to order these kits through the apps. The most common reason for not ordering the HIV/STI kits was preferring to test at a clinic. In interviews, participants expressed feeling empowered by being able to test at home; however, they also raised concerns around STI sample collection.
HIV self-testing and STI self-collection kit ordering via mobile apps is feasible, acceptable and may show promise in increasing testing rates among YMSM. The LYNX and MyChoices apps are currently being tested in a full-scale efficacy trial, and if successful, these innovative mobile apps could be scaled up to efficiently increase HIV/STI testing among youth across the US.
在美国,与男性发生性关系的年轻男性(YMSM)受人类免疫缺陷病毒(HIV)和其他性传播感染(STIs)的影响尤为严重,且HIV/STIs检测率较低。提供HIV自我检测和STIs自我采样可提高检测率,通过移动应用程序(应用)获取这些检测试剂盒有助于促进YMSM进行HIV自我检测和STIs自我采样。
本研究的数据来自青少年试验网络-LYNX和MyChoices内的两项移动应用程序试点随机对照试验(RCTs),旨在提高五个美国城市中近期未进行HIV检测且感染HIV风险较高的YMSM(年龄15-24岁)的HIV/STIs检测率。两款应用都具备订购快速出结果的HIV自我检测试剂盒以及STIs自我采样试剂盒的功能,并可将梅毒、淋病和衣原体样本邮寄至实验室进行检测。通过对应用程序用户在随机分组前、随机分组后3个月和6个月的评估(n=80)以及对应用程序用户的目标样本进行在线访谈的数据(n=37),我们报告了通过应用程序订购HIV自我检测和STIs自我采样试剂盒的经验和教训。
参与者的平均年龄为20.7岁(标准差=2.4),49%为非白人或多种族/族裔。63%的人之前进行过HIV检测。超过一半(58%)的人之前进行过STIs检测,但在过去3个月内进行检测的只有3%。近三分之二的人订购了HIV自我检测试剂盒;其中,75%的人报告在研究期间至少使用了一个自我检测试剂盒。STIs自我采样试剂盒的订购率也很高(54%);然而,STIs自我采样试剂盒的返还率较低(13%),但阳性率较高(5.3%)。HIV自我检测和STIs自我采样试剂盒都非常受欢迎,87%的人报告称能够通过应用程序订购这些试剂盒极其/非常有帮助。未订购HIV/STIs试剂盒的最常见原因是更喜欢在诊所进行检测。在访谈中,参与者表示能够在家中进行检测让他们感到有自主权;然而,他们也对STIs样本采集提出了担忧。
通过移动应用程序订购HIV自我检测和STIs自我采样试剂盒是可行的、可接受的,并且在提高YMSM的检测率方面可能具有前景。LYNX和MyChoices应用目前正在进行全面疗效试验,如果成功,这些创新的移动应用程序可以扩大规模,以有效提高美国各地青少年的HIV/STIs检测率。