Prendiville A, Schulenburg W E
Royal Postgraduate Medical School, Hammersmith Hospital, London.
Arch Dis Child. 1988 May;63(5):522-7. doi: 10.1136/adc.63.5.522.
In the period from September 1983 until June 1986 a prospective study was carried out to determine the incidence and severity of retinopathy of prematurity in inborn infants of less than 1500 g at birth and the risk factors associated with the development of retinopathy of prematurity in infants of less than 31 weeks' gestation. One hundred and forty four infants were eligible for inclusion in the study. Altogether 140 infants of less than 1500 g birth weight were examined, 42 (30%) of whom developed retinopathy of prematurity. Fifteen of these infants had progression to advanced disease (stage III or stage IV). One hundred and seventeen of the infants were of less than 31 weeks' gestation and 34 (29%) of them developed retinopathy of prematurity. Thirty four risk factors shown previously to be associated with the development of the disease were collected prospectively and analysed using multiple logistic regression analysis to determine the independently significant variables. Three risk factors: acidosis, the number of times that the pH was less than 7.2; hyperoxia, the number of times that arterial oxygen tension was greater than 12 kPa; and gestational age were found to be independently associated with the development of retinopathy of prematurity in these infants. These findings suggest that acidosis may be an important aetiological factor in the pathogenesis of this disease.
在1983年9月至1986年6月期间，开展了一项前瞻性研究，以确定出生时体重不足1500克的新生儿早产儿视网膜病变的发病率和严重程度，以及孕周小于31周的婴儿发生早产儿视网膜病变的相关危险因素。144名婴儿符合纳入该研究的条件。总共检查了140名出生体重不足1500克的婴儿，其中42名（30%）发生了早产儿视网膜病变。这些婴儿中有15名病情进展至晚期疾病（III期或IV期）。117名婴儿孕周小于31周，其中34名（29%）发生了早产儿视网膜病变。前瞻性收集了先前显示与该病发生相关的34个危险因素，并使用多元逻辑回归分析进行分析，以确定独立的显著变量。发现三个危险因素：酸中毒，即pH值低于7.2的次数；高氧，即动脉血氧分压大于12 kPa的次数；以及孕周，与这些婴儿发生早产儿视网膜病变独立相关。这些发现表明，酸中毒可能是该疾病发病机制中的一个重要病因因素。
