Gellen B, McIntosh N, McColm J R, Fleck B W
Child Life and Health, Reproductive and Developmental Sciences, Edinburgh University, UK.
Br J Ophthalmol. 2001 Sep;85(9):1044-5. doi: 10.1136/bjo.85.9.1044.
To determine the role of carbon dioxide in the development of retinopathy of prematurity (ROP).
This was a retrospective cohort study of 25 consecutive infants admitted to the neonatal unit with continuously recorded physiological data. The daily mean and standard deviation (SD) of transcutaneous carbon dioxide partial pressure (tcPCO(2)) was compared between infants who had stage 1 or 2 ROP and stage 3 ROP. The time spent hypocarbic (<3 kPa) and/or hypercarbic (>10 kPa and >12 kPa) was also compared between these groups. Intermittent arterial carbon dioxide tension was also measured and compared with the simultaneous tcPCO(2) data.
There were no significant differences in carbon dioxide variability or time spent hypocarbic and/or hypercarbic between the ROP groups on any day. 86% of transcutaneous values were within 1.5 kPa of the simultaneous arterial value.
TcPCO(2) measurement can be a very useful management technique. However, in this cohort neither variable blood carbon dioxide tension nor duration of hypercarbia or hypocarbia in the first 2 weeks of life was associated with the development or severity of ROP.
确定二氧化碳在早产儿视网膜病变（ROP）发展中的作用。
这是一项对25例连续入住新生儿病房且生理数据持续记录的婴儿进行的回顾性队列研究。比较了患有1期或2期ROP的婴儿与3期ROP婴儿的经皮二氧化碳分压（tcPCO₂）的每日均值和标准差（SD）。还比较了这些组之间处于低碳酸血症（<3 kPa）和/或高碳酸血症（>10 kPa和>12 kPa）状态的时间。还测量了间歇性动脉二氧化碳张力并与同时的tcPCO₂数据进行比较。
在任何一天，ROP组之间在二氧化碳变异性或处于低碳酸血症和/或高碳酸血症状态的时间方面均无显著差异。86%的经皮测量值与同时的动脉测量值相差在1.5 kPa以内。
tcPCO₂测量可以是一种非常有用的管理技术。然而，在该队列中，出生后前2周内的可变血液二氧化碳张力以及高碳酸血症或低碳酸血症的持续时间均与ROP的发生或严重程度无关。
