Procianoy R S, Garcia-Prats J A, Hittner H M, Adams J M, Rudolph A J
Acta Paediatr Scand. 1981 Jul;70(4):473-7. doi: 10.1111/j.1651-2227.1981.tb05725.x.
An association between cicatricial retinopathy of prematurity and intraventricular hemorrhage in very low birth weight infants was investigated retrospectively. Newborns were studied who weighed less than or equal to 1500 g at birth, who were less than or equal to 32 weeks gestational age and appropriate by weight, and admitted in the first 24 hours of life to our Neonatal Intensive Care Unit. Diagnosis of retinopathy of prematurity was made by retinal examination at approximately 4 weeks of age. Diagnosis of intraventricular hemorrhage was made by computerized tomography and clinical findings. A total of 138 infants were studied and divided into two groups: (A) birth weight less than or equal to 1000 g (31); (B) birth weight 1001--1500 g (107). There was a statistically significant association between cicatricial retinopathy of prematurity and intraventricular hemorrhage in both groups. There were no statistical differences between birth weight, gestational age, duration of oxygen therapy, highest oxygen concentration received, Apgar scores, incidence of hyaline membrane disease and patent ductus arteriosus between cicatricial retinopathy of prematurity and no retinopathy of prematurity patients in either group. This association may be an important consideration in the pathogenesis of both vascular diseases.
我们对极低出生体重儿的瘢痕性早产儿视网膜病变与脑室内出血之间的关联进行了回顾性研究。研究对象为出生体重小于或等于1500克、胎龄小于或等于32周且体重相称，并在出生后24小时内入住我们新生儿重症监护病房的新生儿。早产儿视网膜病变的诊断在出生后约4周时通过眼底检查进行。脑室内出血的诊断通过计算机断层扫描和临床检查结果确定。总共138例婴儿被纳入研究并分为两组：(A)出生体重小于或等于1000克(31例)；(B)出生体重1001 - 1500克(107例)。两组中瘢痕性早产儿视网膜病变与脑室内出血之间均存在统计学上的显著关联。在两组中，瘢痕性早产儿视网膜病变患者与无早产儿视网膜病变患者在出生体重、胎龄、氧疗持续时间、接受的最高氧浓度、阿氏评分、透明膜病发生率和动脉导管未闭发生率方面均无统计学差异。这种关联可能是这两种血管疾病发病机制中的一个重要考量因素。
