Emon Nazim Uddin, Alam Md Munsur, Uddin Sawon Md Solaman, Rana Ezazul Hoque, Afroj Marufa, Hasan Tanvir Mohammad Mehedi
Department of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Chittagong, 4318, Bangladesh.
Department of Public Health, School of Science and Technology, Bangladesh Open University, Gazipur, 1705, Dhaka, Bangladesh.
Biochem Biophys Rep. 2021 Apr 5;26:100994. doi: 10.1016/j.bbrep.2021.100994. eCollection 2021 Jul.
(Rottl.) (Family: Fabaceae) is an essential medicinal plant for it's conventional uses against a kind of human disorders. This research aims to investigate the antidiarrheal, antibacterial and antifungal properties of the methanol extract of the stems extracts of the (MECD). The antidiarrheal activity of the stem extracts were evaluated by using castor oil-induced diarrhea, castor oil-induced enteropooling and charcoal induced intestinal transit in mice model. Besides, antimicrobial potentiality of MECD was investigated by the disc diffusion method. activity of the isolated compounds were performed by Schrödinger-Maestro (Version 11.1) software. In addition, The ADME/T analysis and PASS prediction were implemented by using pass online tools. In the antidiarrheal investigation, the MECD exhibited a notable inhibition rate in all test approaches which were statistically significant ( < 0.05, < 0.1, < 0.01). MECD 400 mg/kg showed the maximum antidiarrheal potency in all the test methods. antimicrobial analysis unveiled that, MECD revealed higher potentiality against almost all pathogens and indicates dose-dependent activity against almost all the bacteria and fungi. In the case of evaluation of anti-diarrheal, anti-bacterial and anti-fungal activity, all three isolated compounds met the pre-conditions of Lipinski's five rules for drug discovery. Pass predicted study also employed for all compounds. However, The chemical constituents of the can be a potent source of anti-diarrheal, anti-bacterial and anti-fungal medicine and further modification and simulation studies are required to establish the effectiveness of bioactive compounds.
（罗特尔）（豆科）是一种重要的药用植物，因其传统上用于治疗某种人类疾病。本研究旨在研究[植物名称]茎提取物的甲醇提取物（MECD）的止泻、抗菌和抗真菌特性。通过蓖麻油诱导的腹泻、蓖麻油诱导的肠积液和木炭诱导的小鼠肠道转运来评估茎提取物的止泻活性。此外，采用纸片扩散法研究了MECD的抗菌潜力。通过薛定谔-大师（版本11.1）软件对分离化合物的活性进行了测定。此外，利用在线工具进行了ADME/T分析和PASS预测。在止泻研究中，MECD在所有测试方法中均表现出显著的抑制率，具有统计学意义（P<0.05，P<0.1，P<0.01）。MECD 400mg/kg在所有测试方法中显示出最大的止泻效力。抗菌分析表明，MECD对几乎所有病原体都具有较高的潜力，并对几乎所有细菌和真菌表现出剂量依赖性活性。在评估止泻、抗菌和抗真菌活性时，所有三种分离化合物均符合药物发现的Lipinski五条规则的前提条件。对所有化合物也进行了PASS预测研究。然而，[植物名称]的化学成分可能是一种有效的止泻、抗菌和抗真菌药物来源，需要进一步的修饰和模拟研究来确定生物活性化合物的有效性。
