Kite P, Millar M R, Gorham P, Congdon P
Department of Medical Microbiology, General Infirmary, Leeds.
Arch Dis Child. 1988 Jun;63(6):639-43. doi: 10.1136/adc.63.6.639.
The neutrophil count, immature:total neutrophil ratio, C reactive protein assay, nitroblue tetrazolium test and an acridine orange leucocyte cytospin test were evaluated for the diagnosis of neonatal bacteraemia. The acridine orange leucocyte cytospin test gave the highest specificity and positive predictive accuracy, but was less sensitive than the neutrophil count, C reactive protein assay or nitroblue tetrazolium test, particularly for the diagnosis of bacteraemia caused by coagulase negative staphylococci. No single test gave the sensitivity, specificity, and positive predictive accuracy of the combined results of the acridine orange leucocyte cytospin, C reactive protein, and nitroblue tetrazolium tests.
对中性粒细胞计数、未成熟中性粒细胞与总中性粒细胞比例、C反应蛋白测定、硝基蓝四氮唑试验和吖啶橙白细胞甩片试验进行评估，以诊断新生儿菌血症。吖啶橙白细胞甩片试验具有最高的特异性和阳性预测准确性，但敏感性低于中性粒细胞计数、C反应蛋白测定或硝基蓝四氮唑试验，尤其是在诊断由凝固酶阴性葡萄球菌引起的菌血症方面。没有单一试验能达到吖啶橙白细胞甩片试验、C反应蛋白试验和硝基蓝四氮唑试验联合结果的敏感性、特异性和阳性预测准确性。
